ʻO nā palapala pili i ka home a me nā ʻāina ʻē i ka hoʻomākaukau ʻana i nā excipients pharmaceutical hydroxypropyl methylcellulose (HPMC) i nā makahiki i hala iho nei ua loiloi ʻia, nānā ʻia a hōʻuluʻulu ʻia, a me kāna noi ʻana i nā hoʻomākaukau paʻa, hoʻomākaukau wai, hoʻomau a hoʻopaʻa ʻia nā hoʻomākaukau hoʻokuʻu, hoʻomākaukau capsule, gelatin ʻO ka mea hou loa. nā noi ma ke kahua o nā mea hou e like me ka hoʻopili ʻana a me nā bioadhesives. Ma muli o ka ʻokoʻa o ka paona molekala pili a me ka viscosity o HPMC, loaʻa iā ia nā ʻano a me ka hoʻohana ʻana o ka emulsification, adhesion, thickening, viscosity increase, suspending, gelling and film-forming. Hoʻohana nui ʻia ia i ka hoʻomākaukau lāʻau lapaʻau a e pāʻani nui i ka hana o ka hoʻomākaukau. Me ka noiʻi hohonu o kona mau waiwai a me ka hoʻomaikaʻi ʻana i ka ʻenehana hoʻomohala ʻana, e hoʻohana nui ʻia ka HPMC i ka noiʻi ʻana i nā ʻano hoʻohālikelike hou a me nā ʻōnaehana hoʻopuka lāʻau hou, a laila e hāpai i ka hoʻomohala mau ʻana o nā formulations.
hydroxypropyl methylcellulose; hoʻomākaukau lāʻau lapaʻau; nā mea hoʻohui lāʻau.
ʻAʻole nā mea hoʻohana lāʻau lapaʻau wale nō ke kumu kumu no ka hoʻokumu ʻana i ka hoʻomākaukau ʻana i ka lāʻau lapaʻau, akā pili pū kekahi i ka paʻakikī o ka hoʻomākaukau ʻana, ka maikaʻi o ka lāʻau lapaʻau, kūpaʻa, palekana, ka hoʻokuʻu ʻana i ka lāʻau lapaʻau, ke ʻano o ka hana, ka pono lapaʻau, a me ka hoʻomohala ʻana o nā mea hou. nā ʻano dosage a me nā ala hou o ka hoʻokele. pili pili. ʻO ka puka ʻana mai o nā mea hoʻohui lāʻau hou e hoʻoikaika pinepine i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hoʻomākaukau ʻana a me ka hoʻomohala ʻana o nā ʻano dosage hou. ʻO Hydroxypropyl methylcellulose (HPMC) kekahi o nā mea lapaʻau kaulana loa ma ka home a ma waho. Ma muli o kona kaumaha molecular pili like ʻole a me ka viscosity, loaʻa iā ia nā hana o ka emulsifying, hoʻopaʻa, mānoanoa, mānoanoa, hoʻopaneʻe, a gluing. Hoʻohana nui ʻia nā hiʻohiʻona a me nā hoʻohana e like me ka coagulation a me ka hoʻokumu ʻana i ke kiʻiʻoniʻoni i ka ʻenehana lāʻau lapaʻau. Hōʻike nui kēia ʻatikala i ka hoʻohana ʻana o ka hydroxypropyl methylcellulose (HPMC) i nā hana i nā makahiki i hala.
1.Nā waiwai kumu o HPMC
ʻO Hydroxypropyl methyl cellulose (HPMC), ʻo ka molecular formula C8H15O8-(C10 H18O6) n- C8H15O8, a ʻo ka nui o ka molecular pili e pili ana i 86 000. ʻO kēia huahana he mea semi-synthetic, ʻo ia ka hapa o ka methyl a me ka hapa o ka polyhydroxypropyl ether. o ka cellulose. Hiki ke hana ʻia ma nā ʻano ʻelua: ʻO kekahi, ʻo ka methyl cellulose o kahi papa kūpono e mālama ʻia me ka NaOH a laila hana ʻia me ka propylene oxide ma lalo o ka wela kiʻekiʻe a me ke kaomi kiʻekiʻe. Pono e lōʻihi ka manawa o ka hopena e hiki ai i ka methyl a me ka hydroxypropyl ke hana i nā paʻa ether Ua hoʻopili ʻia i ke apo anhydroglucose o cellulose ma ke ʻano o ka cellulose, a hiki ke hiki i ke degere i makemake ʻia; ʻO ka mea ʻē aʻe, ʻo ia ka mālama ʻana i ka pulupulu linter a i ʻole ka pulupulu lāʻau pulupulu me ka caustic soda, a laila e hoʻopili me ka methane chlorinated a me propylene oxide i kēlā me kēia manawa, a laila hoʻomaʻemaʻe hou. , ʻoki ʻia i loko o ka pauka a i ʻole granules maikaʻi.
ʻO ka waihoʻoluʻu o kēia huahana he keʻokeʻo a hiki i ka waiu keʻokeʻo, ʻaʻala ʻole a ʻono ʻole, a ʻo ke ʻano he granular a i ʻole fibrous ka pauka maʻalahi. Hiki ke hoʻoheheʻe ʻia kēia huahana i loko o ka wai e hana i kahi hopena colloidal keʻokeʻo keʻokeʻo me kahi viscosity. Hiki ke hoʻololi ʻia ka sol-gel interconversion ma muli o ka hoʻololi ʻana o ka mahana o ka hoʻonā me kahi ʻano koʻikoʻi.
Ma muli o ka ʻokoʻa o ka ʻike o kēia mau substituent ʻelua i ke ʻano o ka methoxy a me ka hydroxypropyl, ua ʻike ʻia nā ʻano huahana like ʻole. I nā kikoʻī kikoʻī, loaʻa nā ʻano huahana like ʻole. ʻO ka viscosity a me ka wela gelation wela, no laila he ʻokoʻa nā waiwai a hiki ke hoʻohana ʻia no nā kumu like ʻole. ʻO ka Pharmacopoeia o nā ʻāina like ʻole nā lula a me nā hōʻike ʻana ma ke kumu hoʻohālike: ʻO ka European Pharmacopoeia e pili ana i nā māka like ʻole o nā viscosities like ʻole a me nā degere like ʻole o ka hoʻololi ʻana i nā huahana i kūʻai ʻia ma ka mākeke, i hōʻike ʻia e nā māka me nā helu, a ʻo ka ʻāpana "mPa s ”. Ma ka US Pharmacopoeia, hoʻohui ʻia nā huahelu 4 ma hope o ka inoa maʻamau e hōʻike i ka ʻike a me ke ʻano o kēlā me kēia mea pani o hydroxypropyl methylcellulose, e like me hydroxypropyl methylcellulose 2208. ʻO nā huahelu mua ʻelua e hōʻike ana i ka waiwai pili o ka hui methoxy. Pākēneka, hōʻike nā huahelu hope ʻelua i ka pākēneka kokoke o hydroxypropyl.
ʻO ka hydroxypropyl methylcellulose o Calocan he 3 moʻo, ʻo ia hoʻi ka pūʻulu E, pūʻulu F a me ka pūʻulu K, loaʻa i kēlā me kēia moʻo nā hiʻohiʻona like ʻole e koho ai. Hoʻohana nui ʻia ka moʻo E e like me nā uhi kiʻiʻoniʻoni, hoʻohana ʻia no ka uhi ʻana i ka papa, nā cores papa paʻa; Hoʻohana ʻia ka moʻo E, F e like me nā viscosifiers a me ka hoʻokuʻu ʻana i nā mea hoʻomaha no ka hoʻomākaukau ʻana i ka ophthalmic, nā mea hoʻokuʻu, nā mānoanoa no ka hoʻomākaukau ʻana i ka wai, nā papa a me nā Binders of granules; Hoʻohana nui ʻia ʻo K series ma ke ʻano he mea hoʻokuʻu a me ka hydrophilic gel matrix material no ka hoʻomākaukau ʻana i ka hoʻokuʻu lohi.
ʻO nā mea hana hale maʻamau ka Fuzhou No. 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory No. 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co. ., Ltd., Xi'an Huian mea kanu kemika, etc.
2.Nā pono o ka HPMC
Ua lilo ʻo HPMC i hoʻokahi o nā mea hoʻohana lāʻau lapaʻau i hoʻohana nui ʻia ma ka home a ma waho, no ka mea he mau pono ko HPMC ʻaʻole i loaʻa i nā mea kōkua ʻē aʻe.
2.1 Hiki i ka wai anuanu
Hiki ke hoʻoheheʻe ʻia i ka wai anuanu ma lalo o 40 ℃ a i ʻole 70% ethanol, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai wela ma luna o 60 ℃, akā hiki ke gel.
2.2 Kemika inert
ʻO ka HPMC kahi ʻano o ka cellulose ether non-ionic, ʻaʻohe ona ionic charge a ʻaʻole pili pū me nā paʻakai metala a i ʻole nā mea hoʻohui ionic organik, no laila ʻaʻole i pane aku nā mea ʻē aʻe i ka wā o ka hoʻomākaukau ʻana.
2.3 Paʻa
He paʻa ia i ka waika a me ka alkali, a hiki ke mālama ʻia no ka manawa lōʻihi ma waena o ka pH 3 a me 11 me ka ʻole o ka loli nui o ka viscosity. He hopena anti-mildew ka hopena wai o HPMC a mālama i ka paʻa viscosity maikaʻi i ka wā mālama lōʻihi. ʻOi aku ka maikaʻi o ke kūpaʻa o nā mea hoʻohana lāʻau lapaʻau e hoʻohana ana i ka HPMC ma mua o ka poʻe e hoʻohana ana i nā mea kōkua kuʻuna (e like me dextrin, starch, etc.).
2.4 Hoʻoponopono Viscosity
Hiki ke hoʻohui ʻia nā derivatives viscosity like ʻole o HPMC i nā ʻano like ʻole, a hiki ke hoʻololi ʻia kona viscosity e like me kekahi kānāwai, a he pilina laina maikaʻi, no laila hiki ke koho ʻia ka ʻāpana e like me nā pono.
2.5 Metabolic inertness
ʻAʻole hoʻokomo ʻia ʻo HPMC a i ʻole metabolized i loko o ke kino, ʻaʻole hāʻawi i ka wela, no laila he mea hoʻomākaukau lāʻau palekana palekana. 2.6 Palekana Ua manaʻo nui ʻia ʻo HPMC he mea ʻawaʻawa ʻole a hoʻonāukiuki ʻole, ʻo ka nui o ka make ma waena o nā ʻiole he 5 g·kg – 1, a ʻo ka nui o ka make ma waena o nā ʻiole he 5. 2 g · kg – 1. ʻAʻole pōʻino ka nui o kēlā me kēia lā i ke kino o ke kanaka.
3.No ka hoʻohana ʻana i ka HPMC i nā ʻano hana
3.1 E like me ka mea uhi kiʻiʻoniʻoni a me nā mea hana kiʻiʻoniʻoni
Ke hoʻohana nei i ka HPMC ma ke ʻano he papa kiʻiʻoniʻoni, ʻaʻohe pono o ka papa i uhi ʻia i ka uhi ʻana i ka ʻono a me ka hiʻohiʻona i hoʻohālikelike ʻia me nā papa i uhi ʻia e like me nā papa i uhi ʻia i ke kō, akā ʻo kona paʻakikī, friability, moisture absorption, disintegration degree. , ʻoi aku ka maikaʻi o ka loaʻa ʻana o ke kaumaha a me nā hōʻailona maikaʻi ʻē aʻe. Hoʻohana ʻia ka haʻahaʻa haʻahaʻa haʻahaʻa o kēia huahana e like me ka wai-soluble film coating material no nā papa a me nā pila, a hoʻohana ʻia ka māka kiʻekiʻe-viscosity ma ke ʻano he kiʻi ʻoniʻoni kiʻi no nā ʻōnaehana solvent organik, maʻamau ma kahi o 2% a 20. %.
ʻO Zhang Jixing et al. ua hoʻohana i ke ʻano o ka ʻili o ka hopena no ka hoʻopololei ʻana i ka hana premix me HPMC ma ke ʻano he uhi kiʻiʻoniʻoni. ʻO ka lawe ʻana i ka mea hana kiʻiʻoniʻoni HPMC, ka nui o ka waiʻona polyvinyl a me ka plasticizer polyethylene glycol e like me nā kumu hoʻokolokolo, ka ikaika tensile a me ka permeability o ka kiʻiʻoniʻoni a me ka ʻO ka viscosity o ka hopena hoʻopiʻi kiʻiʻoniʻoni ka helu nānā, a me ka pilina ma waena o ka nānā. index a me nā kumu nānā i wehewehe ʻia e kahi kumu hoʻohālike makemakika, a loaʻa ka hana hoʻoponopono maikaʻi loa. ʻO kona hoʻohana ʻana he mea hana kiʻiʻoniʻoni hydroxypropyl methylcellulose (HPMCE5) 11.88 g, polyvinyl alcohol 24.12 g, plasticizer polyethylene glycol 13.00 g, a ʻo ka viscosity suspension coating he 20 mPa·s, ʻo ka permeability a me ka ikaika tensile o ke kiʻi i hiki i ka hopena maikaʻi loa. . Ua hoʻomaikaʻi ʻo Zhang Yuan i ke kaʻina hana hoʻomākaukau, hoʻohana i ka HPMC ma ke ʻano he mea hoʻopaʻa e pani ai i ka slurry starch, a hoʻololi i nā papa Jiahua i nā papa kiʻiʻoniʻoni e hoʻomaikaʻi i ka maikaʻi o kāna hoʻomākaukau ʻana, hoʻomaikaʻi i kona hygroscopicity, maʻalahi e mae, nā papa wehe, splintered a me nā pilikia ʻē aʻe. hoʻonui i ka paʻa papa. Ua hoʻoholo ʻia ke kaʻina hana hoʻomohala maikaʻi loa e nā hoʻokolohua orthogonal, ʻo ia hoʻi, ʻo ka slurry ka hoʻopaʻa ʻana he 2% HPMC ma 70% ethanol solution i ka wā o ka uhi ʻana, a ʻo ka manawa hoʻouluulu i ka granulation he 15 min. Nā hopena Ua hoʻomaikaʻi maikaʻi ʻia nā papa kiʻiʻoniʻoni ʻo Jiahua i hoʻomākaukau ʻia e ke kaʻina hana hou a me ka ʻōlelo kuhikuhi i ka helehelena, ka manawa hemo a me ka paʻakikī kumu ma mua o nā mea i hana ʻia e ka papa kuhikuhi kumu, a ua hoʻomaikaʻi nui ʻia ka helu kūpono o nā papa i uhi ʻia kiʻiʻoniʻoni. ua hiki aku ma mua o 95%. Ua hoʻohana pū ʻo Liang Meiyi, Lu Xiaohui, a me nā mea ʻē aʻe i ka hydroxypropyl methylcellulose e like me ka mea hana kiʻiʻoniʻoni e hoʻomākaukau ai i ka papa hoʻonohonoho ʻana o ka patinae colon a me ka matrine colon positioning papa, kēlā me kēia. pili i ka hoʻokuʻu lāʻau. Ua hoʻomākaukau ʻo Huang Yunran i nā papa hoʻonohonoho ʻana i ke koko koko o Dragon, a ua hoʻopili i ka HPMC i ka hopena o ka uhi ʻana o ka papa pehu, a ʻo kona hapa nui he 5%. Hiki ke ʻike ʻia hiki ke hoʻohana nui ʻia ka HPMC i ka ʻōnaehana hoʻopuka lāʻau lapaʻau.
ʻAʻole ʻo Hydroxypropyl methylcellulose wale nō kahi mea hoʻonaninani kiʻiʻoniʻoni maikaʻi loa, akā hiki ke hoʻohana ʻia ma ke ʻano he mea hana kiʻiʻoniʻoni i nā ʻano kiʻiʻoniʻoni. ʻO Wang Tongshun a me nā mea ʻē aʻe i hoʻopaʻa ʻia i ka palapala hoʻohuihui zinc licorice a me aminolexanol oral composite kiʻiʻoniʻoni, me ka maʻalahi, kūlike, smoothness, transparency o ka mea hana kiʻiʻoniʻoni e like me ka helu ʻimi noiʻi, loaʻa ka palapala kauoha maikaʻi loa he PVA 6.5 g, HPMC 0.1 g a me 6.0 g o propylene glycol e hoʻokō i nā koi o ka hoʻokuʻu lohi a me ka palekana, a hiki ke hoʻohana ʻia e like me ka hoʻomākaukau ʻana o ke kiʻi ʻoniʻoni.
3.2 e like me ka mea hoʻopaʻa a me ka hoʻokaʻawale
Hiki ke hoʻohana ʻia ka haʻahaʻa haʻahaʻa viscosity o kēia huahana ma ke ʻano he mea hoʻopaʻa a me ka disintegrant no nā papa, nā pila a me nā granules, a hiki ke hoʻohana wale ʻia ka māka viscosity kiʻekiʻe ma ke ʻano he binder. ʻOkoʻa ka dosage me nā ʻano like ʻole a me nā koi. ʻO ka maʻamau, ʻo ke ʻano o ka binder no nā papa granulation maloʻo he 5%, a ʻo ke ʻano o ka binder no nā papa granulation maloʻo he 2%.
Ua nānā ʻo Li Houtao et al i ka mea hoʻopaʻa paʻa o nā papa tinidazole. 8% polyvinylpyrrolidone (PVP-K30), 40% syrup, 10% starch slurry, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol i noiʻi ʻia e like me ka hoʻopili ʻana o nā papa tinidazole ma ka huli. ka hoʻomākaukau ʻana i nā papa tinidazole. Ua hoʻohālikelike ʻia nā ʻano hoʻololi o nā papa maʻemaʻe a ma hope o ka uhi ʻana, a ua ana ʻia ka friability, paʻakikī, ka palena manawa hemo a me ka helu hemo ʻana o nā papa kuhikuhi like ʻole. Nā hopena ʻO nā papa i hoʻomākaukau ʻia e 2.0% hydroxypropyl methylcellulose he ʻōlinolino, a ʻaʻohe mea i ʻike ʻia i ke ana friability ʻaʻole i ʻike ʻia ka ʻokiʻoki a me ke kihi ʻana, a ma hope o ka uhi ʻana, ua piha ke ʻano o ka papa a ua maikaʻi ke ʻano. No laila, ua hoʻomākaukau ʻia nā papa tinidazole me 2.0% HPMC-K4 a me 50% ethanol ma ke ʻano he mea hoʻopaʻa. Ua aʻo ʻo Guan Shihai i ke kaʻina hana o Fuganning Tablets, kānana i nā mea hoʻopili, a hoʻopaʻa ʻia i ka 50% ethanol, 15% starch paste, 10% PVP a me 50% ethanol solutions me ka compressibility, smoothness, and friability e like me nā hōʻailona loiloi. , 5% CMC-Na a me 15% HPMC solution (5 mPa s). Nā hopena ʻO nā pepa i hoʻomākaukau ʻia e 50% ethanol, 15% starch paste, 10% PVP 50% ethanol solution a me 5% CMC-Na he ʻili maʻemaʻe, akā maikaʻi ʻole ka compressibility a me ka paʻakikī haʻahaʻa, ʻaʻole hiki ke hoʻokō i nā pono o ka uhi; 15% HPMC solution (5 mPa · s), maʻemaʻe ka ʻili o ka papa, ua kūpono ka friability, a maikaʻi ka compressibility, hiki ke hoʻokō i nā pono o ka uhi. No laila, ua koho ʻia ʻo HPMC (5 mPa s) i mea hoʻopili.
3.3 ma ke ʻano he mea hoʻomaha
Hoʻohana ʻia ka pae kiʻekiʻe-viscosity o kēia huahana ma ke ʻano he mea hoʻomaha no ka hoʻomākaukau ʻana i kahi hoʻomākaukau wai hoʻomaha. He hopena hoʻomaha maikaʻi, maʻalahi e hoʻopuʻi hou, ʻaʻole pili i ka paia, a loaʻa nā ʻāpana flocculation maikaʻi. ʻO ka dosage maʻamau he 0.5% a 1.5%. Mele Tian et al. hoʻohana mau ʻia nā mea polymer (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, etc.) ma ke ʻano he mau mea hoʻomaha no ka hoʻomākaukau ʻana i ka racecadotril. hoʻomaloʻo maloʻo. Ma o ka sedimentation volume ratio o nā ʻokoʻa hoʻokuʻu, ua ʻike ʻia ka redispersibility index, a me ka rheology, suspension viscosity a me microscopic morphology, a ua noiʻi pū ʻia ke kūpaʻa o nā ʻāpana lāʻau ma lalo o ka hoʻokolohua wikiwiki. Nā hualoaʻa ʻO ka hoʻokuʻu maloʻo i hoʻomākaukau ʻia me 2% HPMC ma ke ʻano he hana maʻalahi a me ke kūpaʻa maikaʻi o ka mea hoʻokuʻu.
Ke hoʻohālikelike ʻia me ka methyl cellulose, ʻo ka hydroxypropyl methyl cellulose nā hiʻohiʻona o ka hoʻokumu ʻana i kahi hopena ʻoi aku ka maʻalahi, a he liʻiliʻi wale nō o nā mea fibrous non-dispersed, no laila, hoʻohana mau ʻia ʻo HPMC ma ke ʻano he mea hoʻomaha i ka hoʻomākaukau ophthalmic. Liu Jie et al. hoʻohana ʻia ka HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) a me ka hui pū ʻana o HA/HPMC e like me nā mea hoʻomaha e hoʻomākaukau i nā kikoʻī like ʻole No ka Ciclovir ophthalmic suspension, sedimentation volume ratio, particle size and redispersibility koho ʻia ʻo ia nā hōʻailona nānā e nānā i ka ʻoihana hoʻomaha maikaʻi loa. Hōʻike nā hopena i ka acyclovir ophthalmic suspension i hoʻomākaukau ʻia e 0.05% HA a me 0.05% HPMC ma ke ʻano he mea hoʻopaneʻe, ʻo 0.998 ka nui o ka sedimentation, ʻokoʻa ka nui o ka nui, maikaʻi ka redispersibility, a paʻa ka hoʻomākaukau.
3.4 Ma ke ʻano he blocker, lohi a hoʻokuʻu ʻia a me ka pore-forming agent
Hoʻohana ʻia ka papa kiʻekiʻe viscosity o kēia huahana no ka hoʻomākaukau ʻana i nā papa hoʻokuʻu ʻia o ka hydrophilic gel matrix sustained-release papa, blockers a me nā mea hoʻokuʻu hoʻokuʻu i hoʻokuʻu ʻia o nā papa i hoʻokuʻu ʻia i hoʻokuʻu ʻia, a loaʻa iā ia ka hopena o ka hoʻopaneʻe ʻana i ka lāʻau lapaʻau. ʻO 10% a 80% ka nui o kona hoʻopaʻa ʻana. Hoʻohana ʻia nā māka haʻahaʻa viscosity ma ke ʻano he porogens no ka hoʻomākaukau hoʻokuʻu hoʻomau a hoʻokuʻu ʻia paha. Hiki ke kiʻi koke ʻia ka hopena mua i koi ʻia no ka hopena therapeutic o ia mau papa, a laila hoʻokō ʻia ka hopena hoʻokuʻu a hoʻokuʻu ʻia paha, a mālama ʻia ke ʻano o ka lāʻau lapaʻau kūpono i ke kino. . Hoʻomaʻamaʻa ʻia ka Hydroxypropyl methylcellulose e hana i kahi papa gel i ka wā e hui ai me ka wai. ʻO ke ʻano o ka hoʻokuʻu ʻana i ka lāʻau mai ka papa matrix ka mea nui i ka diffusion o ka papa gel a me ka erosion o ka papa gel. Ua hoʻomākaukau ʻo Jung Bo Shim a me nā papa carvedilol i hoʻokuʻu ʻia me ka HPMC ma ke ʻano he mea hoʻokuʻu mau.
Hoʻohana nui ʻia ka Hydroxypropyl methylcellulose i nā papa matrix hoʻokuʻu mau o ka lāʻau lapaʻau Kina, a ʻo ka hapa nui o nā mea hana, nā ʻāpana kūpono a me nā hoʻomākaukau hoʻokahi o ka lāʻau lapaʻau Kina. Liu Wen et al. ua hoʻohana i ka 15% hydroxypropyl methylcellulose e like me ka matrix material, 1% lactose a me 5% microcrystalline cellulose i mea hoʻopiha, a hoʻomākaukau iā Jingfang Taohe Chengqi Decoction i loko o nā papa hoʻokuʻu hoʻokuʻu ʻia. ʻO ke kumu hoʻohālike ka hoohalike Higuchi. He maʻalahi ka ʻōnaehana haku mele, maʻalahi ka hoʻomākaukau ʻana, a paʻa ka ʻikepili hoʻokuʻu, e kū ana i nā koi o ka Chinese Pharmacopoeia. ʻO Tang Guanguang et al. ua hoʻohana i nā saponins a pau o Astragalus ma ke ʻano he lāʻau hoʻohālike, hoʻomākaukau i nā papa matrix HPMC, a ʻimi i nā mea e pili ana i ka hoʻokuʻu ʻana i ka lāʻau mai nā ʻāpana kūpono o ka lāʻau lapaʻau Kina ma nā papa matrix HPMC. Nā hopena I ka hoʻonui ʻia ʻana o ka nui o ka HPMC, ua emi ka hoʻokuʻu ʻana o ka astragaloside, a ʻo ka pākēneka o ka hoʻokuʻu ʻana o ka lāʻau i pili kokoke i ka laina me ka helu hemo o ka matrix. I loko o ka hypromellose HPMC matrix papa, aia kekahi pilina ma waena o ka hoʻokuʻu ʻana i ka ʻāpana kūpono o ka lāʻau lapaʻau Kina kuʻuna a me ke ʻano a me ke ʻano o ka HPMC, a ʻo ke kaʻina hoʻokuʻu o ka monomer kemika hydrophilic e like me ia. ʻAʻole kūpono ka Hydroxypropyl methylcellulose no nā pūhui hydrophilic, akā no nā mea non-hydrophilic. Ua hoʻohana ʻo Liu Guihua i ka 17% hydroxypropyl methylcellulose (HPMCK15M) ma ke ʻano he mea matrix hoʻokuʻu mau, a ua hoʻomākaukau ʻo Tianshan Xuelian i nā papa matrix hoʻokuʻu ʻia ma o ka granulation pulu a me ke ʻano papa. ʻIke ʻia ka hopena hoʻokuʻu hoʻomau, a paʻa a hiki ke kaʻina hana hoʻomākaukau.
ʻAʻole hoʻohana wale ʻia ka Hydroxypropyl methylcellulose i nā papa matrix hoʻokuʻu mau ʻia o nā mea hana a me nā ʻāpana kūpono o ka lāʻau lapaʻau Kina, akā ʻoi aku ka nui o ka hoʻohana ʻana i ka hoʻomākaukau ʻana i ka lāʻau lapaʻau Kina. Wu Huichao et al. ua hoʻohana i ka 20% hydroxypropyl methyl cellulose (HPMCK4M) i mea matrix, a ua hoʻohana i ke ʻano o ka hoʻopili pololei ʻana i ka pauka no ka hoʻomākaukau ʻana i ka Yizhi hydrophilic gel matrix papa i hiki ke hoʻokuʻu mau i ka lāʻau no 12 mau hola. Ua hoʻohana ʻia ʻo Saponin Rg1, ginsenoside Rb1 a me Panax notoginseng saponin R1 i mau hōʻailona loiloi no ka noiʻi ʻana i ka hoʻokuʻu ʻana i loko o ka vitro, a ua hoʻokomo ʻia ka hoʻohālikelike hoʻokuʻu lāʻau no ke aʻo ʻana i ka mīkini hoʻokuʻu lāʻau. Nā hualoaʻa Ua like ka mīkini hoʻokuʻu lāʻau lapaʻau me ka zero-order kinetic equation a me ka Ritger-Peppas equation, kahi i hoʻokuʻu ʻia ai ka geniposide e ka non-Fick diffusion, a ua hoʻokuʻu ʻia nā mea ʻekolu o Panax notoginseng e ka skeletal erosion.
3.5 Ke kāpili pale e like me ka mānoanoa a me ka colloid
Ke hoʻohana ʻia kēia huahana ma ke ʻano he mānoanoa, ʻo ka helu pākēneka maʻamau he 0.45% a 1.0%. Hiki iā ia ke hoʻonui i ka paʻa o ka hydrophobic glue, hana i kahi colloid pale, pale i nā ʻāpana mai ka coalescing a me ka agglomerating, a laila e pale ai i ka hoʻokumu ʻana o nā sediments. ʻO kāna helu pākēneka maʻamau he 0.5% a 1.5%.
ʻO Wang Zhen et al. ua hoʻohana i ke ʻano hoʻolālā hoʻokolohua orthogonal L9 no ka noiʻi ʻana i ke kaʻina hana hoʻomākaukau o ka lāʻau lāʻau carbon enema. ʻO nā kūlana kaʻina hana maikaʻi loa no ka hoʻoholo hope loa o ka lāʻau lapaʻau i hoʻohana ʻia i ka carbon enema ʻo ia ka hoʻohana ʻana i ka 0.5% sodium carboxymethyl cellulose a me 2.0% hydroxypropyl methylcellulose (HPMC he 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) ma ke ʻano he mānoanoa, kōkua ke ʻano o ke kaʻina hana i ka hoʻonui ʻana i ka hana. paʻa o ka lāʻau kalapona hoʻōla. ʻO Zhang Zhiqiang et al. ua hoʻomohala i ka levofloxacin hydrochloride ophthalmic i hoʻohana ʻia me ka hopena hoʻokuʻu mau, me ka hoʻohana ʻana i ka carbopol ma ke ʻano he gel matrix a me ka hydroxypropyl methylcellulose ma ke ʻano he mānoanoa. ʻO ka lāʻau lapaʻau maikaʻi loa ma ka hoʻokolohua, loaʻa i ka hopena maikaʻi loa ka levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen phosphate 0.35 g, phosphoric acid 0.45 g sodium dihydrogen, 0.50 g sodium dihydrogen, 0.50 g sodium. , 0.03 g o ka ethyl paraben, a hoʻohui ʻia ka wai i 100 mL. I ka hoʻāʻo ʻana, ua nānā ka mea kākau i ka hydroxypropyl methylcellulose METHOCEL series o Colorcon Company me nā kikoʻī like ʻole (K4M, E4M, E15 LV, E50LV) e hoʻomākaukau i nā mānoanoa me nā ʻokoʻa like ʻole, a ʻo ka hopena i koho ʻia ʻo HPMC E50 LV e like me ka mānoanoa. Mea mānoanoa no ka pH-sensitive levofloxacin hydrochloride gels koke.
3.6 e like me ka mea capsule
ʻO ka mea maʻamau, ʻo ka gelatin ka mea nui o ka pūpū capsule. He maʻalahi ke kaʻina hana o ka pūpū capsule, akā aia kekahi mau pilikia a me nā hanana e like me ka pale maikaʻi ʻole i ka wai a me nā lāʻau lapaʻau oxygen-sensitive, hoʻemi ʻia ka hoʻopau ʻana o ka lāʻau, a me ka hoʻokaʻulua ʻana o ka pūpū capsule i ka wā mālama. No laila, hoʻohana ʻia ka hydroxypropyl methylcellulose i mea pani no ka gelatin capsules no ka hoʻomākaukau ʻana i nā capsules, kahi e hoʻomaikaʻi ai i ka hana ʻana o ka capsule formability a me ka hopena hoʻohana, a ua hoʻolaha nui ʻia ma ka home a ma waho.
Ke hoʻohana nei i ka theophylline ma ke ʻano he lāʻau hoʻomalu, Podczeck et al. ua ʻike ʻia ʻoi aku ka nui o ka hoʻoheheʻe ʻana i ka lāʻau o nā capsules me nā pūpū hydroxypropyl methylcellulose ma mua o nā capsules gelatin. ʻO ke kumu o ka nānāʻana,ʻo ka hoʻopauʻiaʻana o ka HPMC ka hoʻopauʻana o ka capsule holoʻokoʻa i ka manawa hoʻokahi,ʻoiaiʻo ka weheʻana o ka gelatin capsule ka hoʻopau muaʻana o ka pūnaewele pūnaewele, a laila ka weheʻana o ka capsule holoʻokoʻa, pēlā ka ʻOi aku ka maikaʻi o ka HPMC capsule no nā pūpū Capsule no ka hoʻokuʻu koke ʻana. ʻO Chiwele et al. loaʻa pū i nā hopena like a hoʻohālikelike i ka hoʻoheheʻe ʻana o ka gelatin, gelatin/polyethylene glycol a me nā pūpū HPMC. Ua hōʻike ʻia nā hopena ua hoʻoheheʻe ʻia nā pūpū HPMC ma lalo o nā kūlana pH like ʻole, ʻoiai nā capsules gelatin Ua hoʻopilikia nui ʻia e nā kūlana pH like ʻole. ʻO Tang Yue et al. ua hoʻopaʻa ʻia i kahi ʻano hou o ka pūpū capsule no ka lāʻau haʻahaʻa haʻahaʻa blank maloʻo maloʻo inhaler ʻōnaehana lawe. Ke hoʻohālikelike ʻia me ka pūpū capsule o ka hydroxypropyl methylcellulose a me ka shell capsule o ka gelatin, ua noiʻi ʻia ke kūpaʻa o ka pūpū capsule a me nā waiwai o ka pauka i loko o ka pūpū ma lalo o nā kūlana like ʻole, a ua hoʻokō ʻia ka hoʻāʻo friability. Hōʻike nā hopena i ka hoʻohālikelike ʻia me nā capsules gelatin, ʻoi aku ka maikaʻi o nā pūpū capsule HPMC i ke kūpaʻa a me ka pale ʻana i ka pauka, ʻoi aku ka ikaika o ka moisture kū'ē, a he haʻahaʻa haʻahaʻa ma mua o nā pūpū capsule gelatin, no laila ʻoi aku ka maikaʻi o nā pūpū capsule HPMC no Capsules no ka inhalation pauda maloʻo.
3.7 ma ke ʻano he bioadhesive
Hoʻohana ka ʻenehana Bioadhesion i nā mea hoʻohui me nā polymers bioadhesive. Ma ka hoʻopili ʻana i ka mucosa biological, hoʻonui ia i ka hoʻomau a me ka paʻa o ka pilina ma waena o ka hoʻomākaukau ʻana a me ka mucosa, i hoʻokuʻu mālie ʻia ka lāʻau lapaʻau e ka mucosa e hoʻokō i ke kumu o ka mālama ʻana. Hoʻohana nui ia i kēia manawa. ʻO ka mālama ʻana i nā maʻi o ka ʻōpū o ka ʻōpū, ka waha, ka mucosa waha a me nā ʻāpana ʻē aʻe.
ʻO ka ʻenehana bioadhesion gastrointestinal kahi ʻōnaehana lawe lāʻau hou i kūkulu ʻia i nā makahiki i hala. ʻAʻole ia e hoʻolōʻihi i ka manawa noho o ka hoʻomākaukau ʻana i ka lāʻau lapaʻau ma ka ʻōpū o ka ʻōpū, akā hoʻomaikaʻi pū i ka hana pili ma waena o ka lāʻau a me ka membrane cell ma ka wahi absorption, hoʻololi i ka wai o ka membrane cell, a hana i ke komo ʻana o ka lāʻau i loko. hoʻonuiʻia nā pūnaewele epithelial'ōpū liʻiliʻi, a laila e hoʻomaikaʻi ai i ka bioavailability o ka lāʻau. Wei Keda et al. ua pale i ka ʻōlelo kuhikuhi papa me ke ʻano o ka HPMCK4M a me Carbomer 940 ma ke ʻano he kumu hoʻokolokolo, a ua hoʻohana i kahi mea bioadhesion i hana ponoʻī ʻia e ana i ka ikaika peeling ma waena o ka papa a me ka biofilm simulated e ka maikaʻi o ka wai i loko o ka ʻeke plastik. , a hope koho i ka maʻiʻo o ka HPMCK40 a me ka carbomer 940 i 15 a me 27.5 mg i loko o ka maikai prescription wahi o NCaEBT papa cores, pakahi, e hoomakaukau i ka NCaEBT papa cores, e hoike ana i bioadhesive mea (e like me hydroxypropyl methylcellulose) hiki ke hoemi loa i ka Improve. ka pili ana o ka hoomakaukau ana i ke kino.
ʻO ka hoʻomākaukau bioadhesive waha he ʻano hou o ka ʻōnaehana lawe lāʻau i aʻo hou ʻia i nā makahiki i hala. Hiki i nā hoʻomākaukau bioadhesive waha ke hoʻopili i ka lāʻau i ka ʻāpana i hoʻopilikia ʻia o ka waha waha, ʻaʻole ia e hoʻolōʻihi i ka manawa noho o ka lāʻau i loko o ka mucosa waha, akā pale pū kekahi i ka mucosa waha. ʻOi aku ka hopena therapeutic a hoʻomaikaʻi i ka bioavailability lāʻau. Xue Xiaoyan et al. optimized ka haku mele 'ana o ka insulin waha adhesive papa, me ka apple pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) a me ka sodium alginate e like me bioadhesive mea, a me ka hoʻomaloʻo maloʻo e hoomakaukau i ka insulin waha. Pepa papa lua paʻa. ʻO ka papa hoʻopaʻa waha waha i hoʻomākaukau ʻia he ʻano porous like me ka sponge, kahi kūpono no ka hoʻokuʻu ʻana o ka insulin, a he papa pale hydrophobic, hiki ke hōʻoia i ka hoʻokuʻu unidirectional o ka lāʻau a pale i ka nalowale o ka lāʻau. Hao Jifu et al. Ua hoʻomākaukau pū ʻia nā peʻa polū-melemele oral bioadhesive patches me ka hoʻohana ʻana i ke kāpili Baiji, HPMC a me ka carbomer e like me nā mea bioadhesive.
I nā ʻōnaehana lawe lāʻau lapaʻau, ua hoʻohana nui ʻia ka ʻenehana bioadhesion. ʻO Zhu Yuting et al. hoʻohana i ka carbomer (CP) a me HPMC ma ke ʻano he mea hoʻopili a me ka matrix hoʻokuʻu hoʻomau e hoʻomākaukau i nā clotrimazole bioadhesive vaginal papa me nā ʻano hana like ʻole a me nā ratios, a ana i ko lākou adhesion, manawa adhesion a me ka pehu pākēneka i loko o ke kaiapuni o ka wai kūlohelohe. , ua hoʻopaʻa ʻia ka ʻōlelo kuhikuhi kūpono e like me CP-HPMC1: 1, ʻo ka pepa adhesive i hoʻomākaukau ʻia he hana adhesion maikaʻi, a ua maʻalahi ke kaʻina hana.
3.8 e like me ka gel topical
Ma ke ʻano he hoʻomākaukau adhesive, loaʻa i ka gel kahi ʻano o nā pono e like me ka palekana, ka nani, ka hoʻomaʻemaʻe maʻalahi, ke kumu kūʻai haʻahaʻa, ke kaʻina hana hoʻomākaukau maʻalahi, a me ka launa maikaʻi me nā lāʻau lapaʻau. Kuhikuhi o ka hooulu ana. No ka laʻana, ʻo ka transdermal gel kahi ʻano dosage hou i aʻo hou ʻia i nā makahiki i hala. ʻAʻole hiki iā ia ke pale wale i ka luku ʻana i nā lāʻau lapaʻau i loko o ka ʻōpū o ka ʻōpū a hōʻemi i ka hoʻololi ʻana o ka peak-to-trough o ka nui o ka lāʻau lapaʻau koko, akā ua lilo pū kekahi o nā ʻōnaehana hoʻokuʻu lāʻau kūpono e lanakila ai i nā hopena ʻaoʻao. .
ʻO Zhu Jingjie et al. ua aʻo i ka hopena o nā matrices like ʻole ma ka hoʻokuʻu ʻana o ka scutellarin alcohol plastid gel in vitro, a ua hoʻopaʻa ʻia me ka carbomer (980NF) a me ka hydroxypropyl methylcellulose (HPMCK15M) e like me nā matrices gel, a loaʻa ka scutellarin kūpono no ka scutellarin. Gel matrix o ka waiʻona plastids. Hōʻike nā hopena hoʻokolohua ʻo 1. 0% carbomer, 1. 5% carbomer, 1. 0% carbomer + 1. 0% HPMC, 1. 5% carbomer + 1. 0% HPMC ma ke ʻano he gel matrix Ua kūpono lāua ʻelua no ka plastids alcohol scutellarin. . I ka wā o ka hoʻokolohua, ua ʻike ʻia hiki i ka HPMC ke hoʻololi i ke ʻano hoʻokuʻu lāʻau o ka carbomer gel matrix ma ka hoʻopili ʻana i ka hoʻohālikelike kinetic o ka hoʻokuʻu lāʻau, a hiki i ka 1.0% HPMC ke hoʻomaikaʻi i ka 1.0% carbomer matrix a me 1.5% carbomer matrix. ʻO ke kumu paha ka hoʻonui wikiwiki ʻana o ka HPMC, a ʻo ka hoʻonui wikiwiki ʻana i ka hoʻomaka ʻana o ka hoʻokolohua e hoʻonui ai i ka molecular āpau o ka carbomer gel material, a laila e hoʻolōʻihi i kāna lāʻau hoʻokuʻu lāʻau. Zhao Wencui et al. hoʻohana i ka carbomer-934 a me ka hydroxypropyl methylcellulose e like me nā mea lawe e hoʻomākaukau i ka gel ophthalmic norfloxacin. He maʻalahi a hiki ke kaʻina hana hoʻomākaukau, a kūpono ka maikaʻi i ka gel ophthalmic o "Pharmacopoeia Kina" (2010 edition) Nā koi kūpono.
3.9 ʻO ka mea hoʻopale wai no ka ʻōnaehana microemulsifying ponoʻī
ʻO ka ʻōnaehana hoʻopuka lāʻau pono-microemulsifying (SMEDDS) he ʻano hou o ka ʻōnaehana hāʻawi lāʻau waha, ʻo ia ka hui like ʻole, kūpaʻa a maopopo i haku ʻia me ka lāʻau, ka ʻaila, ka emulsifier a me ka co-emulsifier. He mea maʻalahi ka hoʻohui ʻana o ka lāʻau lapaʻau, a maikaʻi ka palekana a me ke kūpaʻa. No nā lāʻau lapaʻau maikaʻi ʻole, hoʻohui pinepine ʻia nā mea polymer fiber polymer wai-soluble, e like me HPMC, polyvinylpyrrolidone (PVP), etc., e hana i nā lāʻau lapaʻau manuahi a me nā lāʻau lapaʻau i hoʻopili ʻia i loko o ka microemulsion e hoʻokō i ka dissolution supersaturated i loko o ka ʻōpū o ka ʻōpū. hoʻonui i ka solubility lāʻau a hoʻomaikaʻi i ka bioavailability.
ʻO Peng Xuan et al. hoʻomākaukau i kahi ʻōnaehana lawe lāʻau lapaʻau hoʻoheheʻe nui silibinin supersaturated (S-SEDDS). Oxyethylene hydrogenated castor aila (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) e like me ka co-emulsifier, a me 50 mg · g-1 HPMC. Hiki i ka hoʻohui ʻana i ka HPMC iā SSEDDS ke supersaturate i ka silibinin manuahi e hoʻoheheʻe ʻia i loko o S-SEDDS a pale i ka silibinin mai ke kahe ʻana i waho. Ke hoʻohālikelike ʻia me nā hoʻokumu ʻana o ka microemulsion kuʻuna, hoʻohui pinepine ʻia ka nui o ka surfactant no ka pale ʻana i ka encapsulation lāʻau. Hiki i ka hoʻohui ʻana o HPMC ke hoʻomau i ka solubility o ka silibinin i loko o ka dissolution medium me kahi mau, e hōʻemi ana i ka emulsification i loko o nā formulations microemulsion ponoʻī. ana o ka mea hana.
4. Ka hopena
Hiki ke ʻike ʻia ua hoʻohana nui ʻia ʻo HPMC i ka hoʻomākaukau ʻana ma muli o kāna mau waiwai kino, kemika a me ke olaola, akā he nui nā hemahema o ka HPMC i ka hoʻomākaukau ʻana, e like me ke ʻano o ka hoʻokuʻu ʻana ma mua a ma hope o ka hemo ʻana. methyl methacrylate) e hoʻomaikaʻi. I ka manawa like, ua noiʻi kekahi poʻe noiʻi i ka hoʻohana ʻana i ka manaʻo osmotic ma HPMC ma ka hoʻomākaukau ʻana i nā papa hoʻokuʻu hoʻokuʻu ʻia ʻo carbamazepine a me nā papa hoʻokuʻu hoʻokuʻu ʻia verapamil hydrochloride e aʻo hou i kāna hana hoʻokuʻu. Ma kahi huaʻōlelo, ʻoi aku ka nui o nā mea noiʻi e hana nei i nā hana he nui no ka noi maikaʻi ʻana o ka HPMC i ka hoʻomākaukau ʻana, a me ka noiʻi hohonu ʻana o kāna mau waiwai a me ka hoʻomaikaʻi ʻana i ka ʻenehana hoʻomākaukau, e hoʻohana nui ʻia ʻo HPMC i nā ʻano hana hou. a me nā ʻano mea hoʻohana hou. I ka noiʻi ʻana o ka ʻōnaehana lāʻau lapaʻau, a laila paipai i ka hoʻomohala mau ʻana o ka lāʻau lapaʻau.
Ka manawa hoʻouna: Oct-08-2022