Ua kapa ʻia ʻo HPMC he hydroxypropyl methylcellulose.
Koho ka huahana HPMC i ka pulupulu maʻemaʻe maʻemaʻe ma ke ʻano he mea maka a hana ʻia e ka etherification kūikawā ma lalo o nā kūlana alkaline.Hoʻopau ʻia ke kaʻina holoʻokoʻa ma lalo o nā kūlana GMP a me ka nānā pono ʻana, me ka ʻole o nā mea hana e like me nā mea holoholona a me ka momona.
Nā waiwai HPMC:
ʻO ka huahana HPMC he non-ionic cellulose ether, ʻo ke ʻano he pauka keʻokeʻo, ʻono ʻole, hiki ke hoʻoheheʻe ʻia i ka wai a me ka hapa nui o nā mea hoʻoheheʻe polar (e like me dichloroethane) a me ka ʻāpana kūpono o ka ethanol/wai, propyl alcohol/water, etc. ʻoihana, ʻike maopopo a me ka hana paʻa.Loaʻa i ka HPMC nā waiwai o ka gel thermal, ua wela ka hopena wai o ka huahana e hana i ka ua gel, a laila hoʻoheheʻe ʻia ma hope o ka hoʻoluʻu ʻana, ʻokoʻa nā kikoʻī o ka wela gel huahana.Hoʻololi ka solubility me ka viscosity, ka haʻahaʻa o ka viscosity, ʻoi aku ka nui o ka solubility, ʻokoʻa nā kikoʻī o HPMC i kekahi ʻokoʻa i kona mau waiwai, ʻaʻole pili ʻo HPMC i ka wai i ka waiwai PH.ʻOi aku ka nui o nā ʻāpana: 100 mesh pass rate ma mua o 100%.ʻAno nui: 0.25-0.70g/ (maʻa mau ma kahi o 0.5g/), ʻumekaumaha kikoʻī 1.26-1.31.Ka wela hoʻololi: 190-200 ℃, ka mahana carbonization: 280-300 ℃.ʻO ke kuʻekuʻe ʻana o ka ʻili: 42-56dyn/cm i 2% wai hoʻonā.Me ka hoʻonui ʻana o ka methoxyl content, ua emi ka helu gel, ua hoʻonui ʻia ka hoʻoheheʻe wai, a ua hoʻonui pū ʻia ka hana ma luna.Loaʻa i ka HPMC nā hiʻohiʻona o ka mānoanoa, ka paʻakai, ka lehu haʻahaʻa, ka paʻa o ka PH, ka paʻa ʻana o ka wai, ke kūpaʻa dimensional, ka hana kiʻiʻoniʻoni maikaʻi loa a me ke kūʻē nui ʻana i ka enzyme, dispersity a me ka cohesiveness.
Nā noi HPMC:
1. Papa uʻi: HPMC hoʻohana 'ia e like me ke kiʻiʻoniʻoni mea i loko o ka hoʻomākaukau paʻa, hiki ke hana paʻakikī, laumania a me ka nani kiʻiʻoniʻoni, ka hoʻohana 'ana o 2% -8%.Ma hope o ka uhiʻana, hoʻonuiʻia ka paʻa o ka mea hana i ka māmā, ka wela a me ka haʻahaʻa;ʻAʻohe ʻono a ʻala ʻole, maʻalahi ke lawe, a me ka puaʻa HPMC, pale lā, nā lubricants a me nā mea kūpono maikaʻi ʻē aʻe.ʻO ka uhi maʻamau: ka wai a i ʻole 30-80% ethanol e hoʻopau i ka HPMC, me ka 3-6% solution, e hoʻohui i nā mea kōkua (e like me: ka wela o ka lepo -80, ka aila castor, PEG400, talc, etc.).
2. Enteric-soluble coating layer: ma ka ʻili o nā papa a me nā granules, ua hoʻohana mua ʻia ka uhi ʻana o ka HPMC e like me ka papa hoʻokaʻawale o lalo, a laila uhi ʻia me kahi papa o ka HPMCP enteric-soluble material.Hiki i ke kiʻiʻoniʻoni HPMC ke hoʻomaikaʻi i ke kūpaʻa o ka mea hoʻoheheʻe enteric-soluble i ka waiho ʻana.
3. Hoʻomākaukau hoʻokuʻu mau: me ka hoʻohana ʻana i ka HPMC ma ke ʻano he pore-inducing agent a me ka hilinaʻi ʻana i ka ethyl cellulose ma ke ʻano he iwi iwi, hiki ke hana ʻia nā papa hana lōʻihi.
4. Thickening agent a me colloid pale pale adhesive a me ka maka kulu: HPMC no ka mānoanoa mea maʻamau i hoʻohana 'ia ka manaʻo o 0.45-1%.
5. Hoʻopili: HPMC ma ke ʻano he mea hoʻopaʻa maʻamau o 2% -5%, hoʻohana ʻia e hoʻomaikaʻi i ka paʻa o ka hydrophobic adhesive, hoʻohana maʻamau ʻia o 0.5-1.5%.
6. Agena hoʻopaneʻe, luna hoʻokuʻu hoʻokuʻu a me ka mea hoʻokuʻu.Mea hoʻokuʻu: ʻo ka maʻamau maʻamau o ka mea hoʻokuʻu ʻia he 0.5-1.5%.
7. Meaʻai: HPMC like thickening agent i hoʻohui ʻia i nā ʻano mea inu, nā huahana waiu, condiments, nutritional food, as thickening agent, binder, emulsifier, suspension agent, stabilizer, water retention agent, excifer, etc.
8. Hoʻohana ʻia i nā mea hoʻonaninani e like me nā adhesives, emulsifiers, film forming agents, etc.
Ka manawa hoʻouna: Jan-14-2022