ʻO ka Hydroxypropyl Methylcellulose (HPMC) he mea waiwai nui ka cellulose ether derivative i hoʻohana nui ʻia i nā ʻoihana ʻoihana he nui ma muli o kāna mau waiwai kino a me nā kemika.ʻO kāna mau waiwai viscosity kekahi o nā waiwai koʻikoʻi o HPMC, e pili pono ana i kāna hana i nā noi like ʻole.
1. Nā waiwai kumu o HPMC
ʻO ka HPMC he cellulose ether nonionic i loaʻa ma ka hoʻololi ʻana i kahi hapa o nā pūʻulu hydroxyl (–OH) i loko o ka molekele cellulose me nā pūʻulu methoxy (–OCH3) a me nā pūʻulu hydroxypropyl (–OCH2CH(OH)CH3).Loaʻa iā ia ka solubility maikaʻi i ka wai a me kekahi mau mea hoʻoheheʻe organik, e hana ana i nā hopena colloidal transparent.Hoʻoholo nui ʻia ka viscosity o HPMC e kona kaumaha molekala, degere o ka hoʻololi ʻana (DS, Degree of Substitution) a me ka hāʻawi ʻana.
2. Ka hoʻoholo ʻana o ka viscosity o HPMC
Hoʻohana pinepine ʻia ka viscosity o ka HPMC me ka hoʻohana ʻana i ka viscometer rotational a i ʻole ka viscometer capillary.I ke ana ana, pono e uku i ka noonoo, ka wela a me ka shear rate o ka hopena, no ka mea, hiki i keia mau mea ke hoololi nui i ka waiwai viscosity.
ʻO ka hoʻonā hopena: Piʻi ka viscosity o ka HPMC me ka piʻi ʻana o ka hoʻonā.Ke emi iho ka neʻe ʻana o ka hopena HPMC, ʻoi aku ka nāwaliwali o ka pilina ma waena o nā molekala a ʻoi aku ka haʻahaʻa o ka viscosity.Ke piʻi aʻe ka manaʻo, piʻi ka entanglement a me ka pilina ma waena o nā molekala, e hoʻonui nui i ka viscosity.
Ka Mahana: ʻO ka viscosity o nā haʻina HPMC he maʻalahi loa i ka wela.ʻO ka maʻamau, i ka piʻi ʻana o ka mahana, e emi ana ka viscosity o ka hopena HPMC.ʻO kēia ma muli o ka hoʻonui ʻana i ka mahana e alakaʻi ana i ka hoʻonui ʻana i ka neʻe ʻana o ka molekala a me ka nāwaliwali o nā pilina intermolecular.Pono e hoʻomaopopo ʻia ʻo ka HPMC me nā degere like ʻole o ka hoʻololi ʻana a me ke kaumaha molekala he ʻokoʻa ka naʻau i ka mahana.
Laki ʻāhi: Hōʻike nā ʻōhua HPMC i ke ʻano pseudoplastic (shear thinning), ʻo ia hoʻi, ʻoi aku ka kiʻekiʻe o ka viscosity i nā haʻahaʻa ʻoki haʻahaʻa a e emi ana i ka nui o ka shear rate.ʻO kēia ʻano hana ma muli o nā pūʻali ʻāwili e hoʻolike i nā kaulahao molekala ma ka ʻaoʻao shear, a laila e hōʻemi ana i nā entanglements a me nā pilina ma waena o nā molekala.
3. Nā mea e pili ana i ka viscosity HPMC
ʻO ke kaumaha molekala: ʻO ke kaumaha o ka HPMC kekahi o nā kumu nui e hoʻoholo ai i kona viscosity.Ma ka ʻōlelo maʻamau, ʻoi aku ka nui o ke kaumaha molekala, ʻoi aku ka kiʻekiʻe o ka viscosity o ka hopena.ʻO kēia no ka mea, ʻoi aku ka nui o nā molekala HPMC me ke kaumaha molekala kiʻekiʻe e hana i nā ʻupena i hoʻopili ʻia, ma laila e hoʻonui ai i ka friction kūloko o ka hopena.
Degere o ka hoʻololi a me ka hāʻawi ʻana: ʻO ka helu a me ka hāʻawi ʻana o ka methoxy a me ka hydroxypropyl substituent ma HPMC e pili pū i kona viscosity.ʻO ka maʻamau, ʻoi aku ka kiʻekiʻe o ke kiʻekiʻe o ka methoxy substitution (DS), ʻoi aku ka haʻahaʻa o ka viscosity o HPMC, no ka mea, ʻo ka hoʻokomo ʻana i nā mea pani methoxy e hōʻemi i ka ikaika hoʻopaʻa hydrogen ma waena o nā mole.ʻO ka hoʻokomo ʻana i nā mea pani hydroxypropyl e hoʻonui i ka pilina intermolecular, a laila e hoʻonui ai i ka viscosity.Eia kekahi, ʻo ka hāʻawi like ʻana o nā substituent e kōkua i ka hana ʻana i kahi ʻōnaehana hoʻonā kūpaʻa a hoʻonui i ka viscosity o ka hopena.
pH waiwai o ka hoʻonā: ʻOiai ʻo HPMC he polymer non-ionic a ʻaʻole i maʻalahi kona viscosity i nā loli i ka waiwai pH o ka hopena, hiki i nā waiwai pH kiʻekiʻe (ʻoi loa ka waikawa a i ʻole ka alkaline) hiki ke hoʻohaʻahaʻa i ke ʻano o ka molekala. HPMC, pela e pili ana i ka viscosity.
4. Nā kahua noi o HPMC
Ma muli o kāna mau hiʻohiʻona viscosity maikaʻi loa, hoʻohana nui ʻia ka HPMC i nā kula he nui:
Nā mea kūkulu hale: Ma nā mea kūkulu hale, hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa a me ka mea mālama wai e hoʻomaikaʻi i ka hana kūkulu ʻana a hoʻonui i ka pale ʻana.
ʻoihana lāʻau lapaʻau: Ma ka ʻoihana lāʻau lapaʻau, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea hoʻopaʻa no nā papa, kahi mea hana kiʻiʻoniʻoni no nā capsules a me kahi mea lawe no nā lāʻau hoʻokuʻu mau.
ʻOihana meaʻai: Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa a me ka stabilizer i ka ʻoihana meaʻai no ka hana ʻana i ka ice cream, jelly a me nā huahana waiu.
Nā huahana kemika i kēlā me kēia lā: I nā huahana kemika i kēlā me kēia lā, hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa a me ka stabilizer no ka hana ʻana i ka shampoo, ka wai ʻauʻau, toothpaste, etc.
ʻO nā hiʻohiʻona viscosity o HPMC ke kumu no kāna hana maikaʻi loa i nā noi like ʻole.Ma ke kaohi ʻana i ke kaumaha molekala, ka pae o ka hoʻololi ʻana, a me nā kūlana hoʻonā o HPMC, hiki ke hoʻoponopono ʻia kona viscosity e hoʻokō i nā pono noi like ʻole.I ka wā e hiki mai ana, ʻo ka noiʻi hohonu e pili ana i ka pilina ma waena o ka ʻano molekala HPMC a me ka viscosity e kōkua i ka hoʻomohala ʻana i nā huahana HPMC me ka hana ʻoi aku ka maikaʻi a hoʻonui i kāna mau noi noi.
Ka manawa hoʻouna: Iulai-20-2024