ʻO Hypromellose, ka mea i kapa ʻia ʻo hydroxypropyl methylcellulose (HPMC), he polymer semi-synthetic versatile i loaʻa mai ka cellulose. Ma muli o kāna mau mea kemika a me ke kino, hoʻohana mau ʻia ʻo HPMC ma ke ʻano he mānoanoa, stabilizer a me ka mea hoʻopili i ka lāʻau lapaʻau, meaʻai a me nā ʻoihana mālama pilikino. Ma kēia ʻatikala, kūkākūkā mākou i ka kemika o nā HPMC a me kā lākou mau noi koʻikoʻi.
1. Hoʻoheheʻe
ʻO kekahi o nā waiwai kemika koʻikoʻi o HPMC ʻo kona solubility. Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai a me nā mea hoʻoheheʻe organik he nui, e lilo ia i mea kūpono no nā ʻōnaehana lawe lāʻau a me nā noi ʻē aʻe e koi ana i ka hemo. Eia naʻe, hoʻoholo nui ʻia ka solubility o HPMC e kona degere o ka pani ʻana (DS), ka mea e hoʻoholo ai i ka helu o nā pūʻulu hydroxypropyl a me methyl i loko o ke kaulahao polymer. ʻO nā HPMC me ka DS kiʻekiʻe he haʻahaʻa haʻahaʻa haʻahaʻa ma muli o ka hoʻonui ʻana i nā pilina intermolecular.
2. Rheology
ʻO kekahi waiwai kemika koʻikoʻi o HPMC ʻo kāna ʻano rheological. Hiki ke hoʻohana ʻia ka hiki ʻana o HPMC e hana i kahi pūnaewele e like me ka gel i ka hydration e hoʻomalu i ka viscosity a me nā ʻano kahe o nā ʻano. Hōʻike pū ka HPMC i ke ʻano kahe kahe ʻole o Newtonian, ʻo ia hoʻi, hoʻololi kona viscosity e like me ka nui o ka shear rate. Hiki ke hoʻomalu houʻia kēia waiwai ma ka hoʻololiʻana i ka manaʻo o HPMC a me DS i ka hoʻolālā.
3. Hoʻokumu kiʻiʻoniʻoni
Hoʻohana nui ʻia ʻo HPMC ma ke ʻano he kiʻiʻoniʻoni mua ma muli o kona hiki ke hana i nā kiʻiʻoniʻoni like ʻole ke hoʻopili ʻia i kahi substrate. ʻO nā waiwai hana kiʻiʻoniʻoni o HPMC e pili ana i kāna DS, viscosity a me ke alo o nā plasticizers, hiki ke hoʻomaikaʻi i ka elasticity a me ka maʻalahi o ke kiʻi. Hoʻohana mau ʻia nā kiʻiʻoniʻoni mai HPMC i ka lawe ʻana i ka lāʻau lapaʻau no ka mea e ʻae lākou i ka hoʻokuʻu ʻia ʻana o nā mea hana.
4. Hoʻohālikelike
ʻO ka HPMC kahi mea hoʻohana kūpono loa a hiki ke hoʻohana ʻia i nā ʻano hana like ʻole. He kūpono ia me ka hapa nui o nā mea lāʻau lapaʻau, me nā mea hana lāʻau lapaʻau ikaika (API) a me nā mea hoʻohui ʻē aʻe i hoʻohana mau ʻia i nā ʻano lāʻau lapaʻau. Hoʻopili pū ʻia ʻo HPMC me nā meaʻai he nui, e lilo ia i koho kaulana no nā noi meaʻai.
5. Paʻa kemika
ʻO ka HPMC kahi polymer kūpaʻa e kūʻē i ka hydrolysis a me nā hopena kemika ʻē aʻe. ʻO kēia kūpaʻa e lilo ia i mea hoʻohui kūpono no nā ʻōnaehana lawe lāʻau e like me ka pale ʻana i ka mea hana mai ka hoʻohaʻahaʻa ʻana a hoʻonui i kona bioavailability. Eia nō naʻe, hiki ke hoʻopili ʻia ka paʻa kemika o HPMC e ka wela kiʻekiʻe, ka haʻahaʻa kiʻekiʻe, a me kekahi mau mea hoʻoheheʻe, hiki ke hoʻohaʻahaʻa i ka polymer a hoʻemi i kona pono i nā hana.
6. Biocompatibility
ʻO ka hope loa, he polymer biocompatible ʻo HPMC i palekana no ka hoʻohana ʻana i nā lāʻau lapaʻau a me nā huahana mālama pilikino. ʻAʻohe mea ʻawaʻawa, non-immunogenic a biodegradable, e hana maikaʻi ia no nā formulations e koi ana i ka liʻiliʻi liʻiliʻi a me ka palekana kiʻekiʻe.
I ka hōʻuluʻulu ʻana, ʻo HPMC hypromellose he polymer multifunctional me ka nui o nā waiwai kemika koʻikoʻi, me ka solubility, rheology, film-forming properties, compatibility, chemical stability, a me biocompatibility. Hana kēia mau waiwai i mea hoʻohiwahiwa kūpono no nā ʻōnaehana lawe lāʻau a me nā noi ʻē aʻe i ka ʻoihana meaʻai a me nā ʻoihana mālama pilikino. Ke hoʻomau nei ka noiʻi i ka hoʻonui ʻana i ko mākou ʻike no nā HPMC, hiki i kā lākou mau waiwai kūʻokoʻa ke loaʻa i nā noi ākea i ka wā e hiki mai ana.
Ka manawa hoʻouna: Iulai-28-2023