ʻO ka Hydroxypropyl Methylcellulose (HPMC) he polymer versatile i hoʻohana ʻia i nā ʻoihana like ʻole me nā lāʻau lapaʻau, ke kūkulu ʻana, ka meaʻai, a me nā mea hoʻonaninani.Loaʻa ia mai ka cellulose, kahi polymer maoli i loaʻa i nā mea kanu.Mahalo nui ʻia ʻo HPMC no kāna mau mea hana kiʻiʻoniʻoni, mānoanoa, hoʻopaʻa, a me ka mālama wai.I ka ʻoihana lāʻau lapaʻau, hoʻohana maʻamau ia ma ke ʻano he mea hoʻohana lāʻau lapaʻau i nā ʻano o ka waha waha, nā hoʻomākaukau ophthalmic, nā kumuhana topical, a me nā ʻōnaehana hoʻopuka lāʻau hoʻokuʻu ʻia.
Hiki ke hoʻokaʻawale ʻia ka HPMC ma muli o nā ʻāpana like me kona kaumaha molekala, degere o ka hoʻololi ʻana, a me ka nui o nā ʻāpana.Eia kahi hiʻohiʻona o nā ʻano like ʻole o HPMC e pili ana i kēia mau ʻāpana:
Ma muli o ke kaumaha Molecular:
HPMC kiʻekiʻe Molecular Weight: ʻO kēia ʻano HPMC he ʻoi aku ka nui o ke kaumaha molekala, e alakaʻi ana i ka hoʻonui ʻana i ka viscosity a me nā waiwai hana kiʻiʻoniʻoni.Hoʻohana pinepine ʻia i nā noi kahi e koi ʻia ai ka viscosity kiʻekiʻe, e like me nā hoʻopuka hoʻokuʻu ʻia.
Haʻahaʻa Molecular Weight HPMC: ʻAʻole, haʻahaʻa molecular kaumaha HPMC he haʻahaʻa viscosity a hoʻohana ʻia i nā noi kahi e makemake ʻia ai ka viscosity haʻahaʻa a me ka hemo wikiwiki.
Ma muli o ka Degree of Substitution (DS):
HPMC Hoʻololi Kiʻekiʻe (HPMC-HS): ʻO HPMC me kahi kiʻekiʻe o ka hoʻololi ʻana e hōʻike maʻamau i ka solubility ʻoi aku ka maikaʻi i ka wai a hiki ke hoʻohana ʻia i nā hana e koi ana i ka hemo wikiwiki.
Hāʻawi ʻia kēia ʻano HPMC i kahi kaulike ma waena o ka solubility a me ka viscosity.Hoʻohana maʻamau ia i nā ʻano lāʻau lapaʻau like ʻole.
HPMC Hoʻololi Haʻahaʻa (HPMC-LS): Hāʻawi ʻo HPMC me kahi haʻahaʻa haʻahaʻa o ka hoʻololi ʻana i nā uku hoʻoheheʻe lohi a me ka viscosity kiʻekiʻe.Hoʻohana pinepine ʻia i nā ʻano hoʻokuʻu hoʻokuʻu mau.
Ma muli o ka nui o ka ʻāpana:
ʻOi aku ka maikaʻi o ke kahe ʻana o ka HPMC: ʻO ka HPMC me ka liʻiliʻi liʻiliʻi e hāʻawi i nā waiwai kahe a makemake pinepine ʻia i nā ʻano mea paʻa e like me nā papa a me nā capsules.
ʻOi aku ka nui o ka nui HPMC: Ua kūpono nā ʻāpana ʻeleʻele no nā noi kahi e makemake ʻia ai ka hoʻokuʻu ʻana a i ʻole nā mea hoʻokuʻu lōʻihi.Hoʻohana pinepine ʻia lākou i nā papa matrix a me nā pellets.
Nā Papa Kūikawā:
HPMC Enteric: Hoʻokumu kūikawā ʻia kēia ʻano HPMC e pale aku i ka wai ʻōpū, hiki iā ia ke hele i loko o ka ʻōpū a hoʻokuʻu i ka lāʻau i loko o ka ʻōpū.Hoʻohana maʻamau ia no nā lāʻau lapaʻau e pili ana i ka gastric pH a i ʻole no ka lawe ʻia ʻana.
Hoʻokuʻu ʻia ʻo HPMC: Ua hoʻolālā ʻia kēia mau mea hana e hoʻokuʻu mālie i ka mea hana no ka manawa lōʻihi, e alakaʻi ana i ka hana lāʻau lōʻihi a hoʻemi i ka pinepine dosing.Hoʻohana pinepine ʻia lākou i nā kūlana maʻi ma kahi o ka mālama mau ʻana i nā pae lāʻau i loko o ke koko he mea koʻikoʻi.
Papa Hui:
HPMC-Acetate Succinate (HPMC-AS): Hoʻohui kēia ʻano HPMC i nā waiwai o ka HPMC a me nā pūʻulu acetyl, e kūpono ana i nā ʻāpana enteric a me nā ʻōnaehana lawe lāʻau pH-sensitive.
HPMC-Phthalate (HPMC-P): ʻO HPMC-P he polymer hilinaʻi pH i hoʻohana mau ʻia i loko o nā uhi komo no ka pale ʻana i ka lāʻau mai nā kūlana ʻakika i loko o ka ʻōpū.
Hoʻohui like ʻia:
Hiki i nā mea hana ke hana i nā hui like ʻole o HPMC me nā polymers ʻē aʻe a i ʻole nā mea hoʻohui e hoʻokō i nā koi kikoʻī e like me ka hoʻomaikaʻi ʻana i nā profile hoʻokuʻu lāʻau, hoʻomaikaʻi i ka paʻa, a i ʻole nā mea hoʻomaʻamaʻa ʻono.
ʻO nā waiwai like ʻole o ka HPMC e ʻae i ka hoʻohana ʻana i nā ʻano lāʻau lapaʻau ākea ākea, kēlā me kēia mea e hoʻokō i nā koi kikoʻī e like me ka solubility, viscosity, release kinetics, a me ke kūpaʻa.ʻO ka hoʻomaopopo ʻana i nā ʻano like ʻole o ka HPMC a me kā lākou mau hiʻohiʻona he mea koʻikoʻi ia no nā mea hoʻolālā e hoʻolālā i nā ʻōnaehana hoʻopuka lāʻau kūpono a maikaʻi.
Ka manawa hoʻouna: Mar-19-2024