He aha ka Hydroxypropyl methyl cellulose HPMC?

Hydroxypropyl methyl cellulose HPMC he non-ionic cellulose i hui pū ʻia i loko o nā ʻano like ʻole a me ka ionic methyl carboxymethyl cellulose i hui pū ʻia eter, ʻaʻole ia e hana me nā metala kaumaha. Hoʻokahi radical oxygen ma muli o ka hydroxypropyl methyl cellulose content a me ka ʻokoʻa o ka ʻokoʻa o ka hydroxypropyl content a me ka viscosity, ua lilo i ʻano ʻokoʻa i ka hana, no ka laʻana, kiʻekiʻe methoxyl content a me nā haʻahaʻa haʻahaʻa o nā ʻano hydroxypropyl, kokoke kāna hana i ka methyl cellulose a me ka methoxyl haʻahaʻa. maʻiʻo a me nā mea kiʻekiʻe o nā ʻano hydroxypropyl, a ua kokoke ka hana i ka hydroxypropyl methyl cellulose i hana ʻia. Akā, i loko o kēlā me kēia ʻano, ʻoiai he liʻiliʻi wale nō ka hydroxypropyl a i ʻole ka methoxy liʻiliʻi, ʻo ka solubility i nā mea hoʻoheheʻe organik a i ʻole ka mahana flocculation i loko o ka wai wai, he ʻokoʻa nui.
 
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose i loko o ka wai solubility o hydroxypropyl methyl cellulose mea maoli he ano propylene oxide (methyl oxypropyl apo) hoololi methyl cellulose, no laila, ua like me ka methyl cellulose wai anuanu soluble a me ka wai wela insoluble ano. Eia naʻe, ʻoi aku ka kiʻekiʻe o ka mahana gelation o ka propyl hydroxy i hoʻololi ʻia ma mua o ka methyl cellulose i ka wai wela. No ka laʻana, ka viscosity o hydroxypropyl methylcellulose aqueous solution me 2% methoxy content DS=0.73 a me ka hydroxypropyl content MS=0.46 he 500 mpa ma 20 ℃. ʻO ka mahana gel o ka huahana S kahi kokoke i 100 ℃, aʻo ka methyl cellulose o ka mahana like ma kahi o 55 ℃ wale nō. E like me kona solubility i loko o ka wai, ua hoʻomaikaʻi maikaʻi ʻia, no ka laʻana, ma hope o ka ʻohi ʻana o ka hydroxypropyl methylcellulose (kahi ʻano palaoa 0.2 ~ 0.5mm ma 20 ℃ 4% aqueous viscosity o 2pA? Hiki ke hoʻoheheʻe ʻia nā huahana S i loko o ka wai me ka ʻole o ka hoʻoluʻu ʻana i ka lumi wela. .
 
(2) Hydroxypropyl methyl cellulose i loko o nā mea hoʻoheheʻe kūlohelohe o ka hydroxypropyl methyl cellulose i loko o nā mea hoʻoheheʻe kūlohelohe, ʻoi aku ka maikaʻi ma mua o ka methyl cellulose, pono ka methyl cellulose i ka methoxy substitution degere o 2.1 a ʻoi aku nā huahana, a loaʻa ka hydroxypropyl MS = 1.5 ~ 1.8 a me ka methoxy. DS=0.2~1.0, High viscosity hydroxypropyl methyl ʻO ka cellulose me ke degere hoʻololi holoʻokoʻa ma luna o 1.8 hiki ke hoʻoheheʻe i ka methanol anhydrous a me ka ethanol solutions, a he thermoplastic a me ka wai solubility. Hiki ke hoʻoheheʻe ʻia i loko o nā hydrocarbons chlorinated e like me dichloromethane a me trichloromethane, a me nā mea hoʻoheheʻe kūlohelohe e like me ka acetone, isopropyl alcohol, a me ka waiʻona diacetone. ʻOi aku ka maikaʻi o kona hoʻoheheʻe ʻana i nā mea hoʻoheheʻe organik ma mua o ka hoʻoheheʻe wai.
 
2, hydroxypropyl methyl cellulose viscosity o nā mea hoʻoikaika
ʻO ka hydroxypropyl methylcellulose viscosity kumu hydroxypropyl methylcellulose ka hoʻoholo viscosity maʻamau, a me nā cellulose ether ʻē aʻe, aia ma 20 ℃ me ka 2% aqueous solution e like me ka hoʻoholo maʻamau. ʻO ka viscosity o ka huahana hoʻokahi, me ka piʻi ʻana o ka neʻe ʻana a me ka hoʻonui ʻana, ke ʻano like ʻole o nā huahana kaumaha molecular like ʻole, ke kaumaha o ka molecular o ka huahana he viscosity kiʻekiʻe. Ua like kona pilina me ka wela me ka methyl cellulose. Ke piʻi ka mahana, hoʻomaka ka emi ʻana o ka viscosity, akā ke hiki i kahi mahana, piʻi koke ka viscosity a puka ka gelation. ʻOi aku ka kiʻekiʻe o ka mahana gelation o nā huahana me ka viscosity haʻahaʻa ma mua o nā huahana me ka viscosity kiʻekiʻe. ʻO ke kiʻekiʻe o kona wahi gel, me ka viscosity kiʻekiʻe a me ka haʻahaʻa o ka ether, akā me ka ether methoxy a me ka hydroxypropyl group composition ratio a me ka huina o ka hoʻololi. Pono e hoʻomaopopo ʻia he pseudoplastic pū kekahi hydroxypropyl methylcellulose; paʻa kona hoʻonā ke mālama ʻia ma ka lumi wela a ʻaʻole hōʻike i ka hoʻohaʻahaʻa o ka viscosity koe wale nō ka hiki ke hoʻohaʻahaʻa i ka enzymatic.
 
3, hydroxypropyl methyl cellulose acid a me ke kūpaʻa alkaline
ʻO ka hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid a me ka alkali, maʻamau ka paʻa, i ka ph PH2 ~ 12 ākea ʻaʻole i hoʻopilikia ʻia, hiki iā ia ke kū i kahi nui o ka waikawa māmā, e like me ka formic acid, acetic acid, citric acid, succinic acid, phosphoric. ʻakika, ʻakika boric, a me nā mea ʻē aʻe. Akā ʻo ka acid concentrated ka hopena o ka hōʻemi ʻana i ka viscosity. ʻAʻohe hopena o ka alkali e like me ka caustic soda, caustic potassium a me ka wai lime, akā e emi mālie ka hopena o ka hoʻonui iki ʻana i ka viscosity o ka hopena i ka wā e hiki mai ana.
 
4, hiki ke hui 'ia ka hydroxypropyl methyl cellulose
Hiki ke hoʻohui ʻia ka hopena hydroxypropyl methyl cellulose me nā pūhui polymer hiki ke hoʻoheheʻe ʻia i ka wai, a lilo i ʻano hoʻonā ʻokoʻa me ka viscosity kiʻekiʻe. ʻO kēia mau pūhui mole kiʻekiʻe he polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane a me ka hydroxyethyl cellulose a me ka methyl cellulose, a me nā mea ʻē aʻe. hoʻonā. Hiki ke hui pū ʻia ka hydroxypropyl methyl cellulose me ka stearic acid a i ʻole palmitic acid mannitol ester a i ʻole sorbitol ester, akā me ka glycerol, sorbitol a me ka mannitol, hiki ke hoʻohana ʻia kēia mau pūhui e like me ka hydroxypropyl methyl cellulose plasticizer.
 
5, hydroxypropyl methyl cellulose hiki ole ke hooheheeia ka wai
Hydroxypropyl methyl cellulose insoluble wai-soluble cellulose etera, hiki i ka ili kea-linking me aldehydes, a hana i keia mau wai-soluble etera precipitated i loko o ka hopena, lilo insoluble i ka wai. A e hana i ka hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, a me nā mea ʻē aʻe, pono ka hoʻohana ʻana i ka formaldehyde e nānā kūikawā i ka waiwai PH o ka hopena, kahi e wikiwiki ai ka hopena o ka glyoxal, no laila i ka hana ʻoihana hoʻohana maʻamau i ka glyoxal e like me ke keʻa. -mea hoʻopili. ʻO ke ʻano o kēia ʻano crosslinking agent i ka hopena he 0.2% ~ 10% o ka ether mass, ʻo ka mea maikaʻi loa ʻo 7% ~ 10%, e like me ka hoʻohana ʻana i ka glyoxal me 3.3% ~ 6% ka mea kūpono loa. ʻO ka mahana mālama maʻamau he 0 ~ 30 ℃, ʻo ka manawa 1 ~ 120min. Pono e hoʻokō ʻia ka hopena hoʻopili keʻa ma lalo o nā kūlana acidic. ʻO ka maʻamau, hoʻohui ʻia ka ʻakika ikaika inorganic a i ʻole ka waikawa carboxylic organik i ka hopena e hoʻoponopono ai i ka PH o ka hopena i kahi 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui ʻia nā aldehydes no ka hoʻopili ʻana i ke keʻa. ʻO nā ʻakika i hoʻohana ʻia he waika hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid a i ʻole citric acid, ma waena o ka waika formic a i ʻole acetic acid ka mea maikaʻi loa, ʻoiai ʻo formic acid ka mea maikaʻi loa. Hiki ke hoʻohui pū ʻia nā ʻakika a me nā aldehydes i ka manawa like e ʻae i ka hoʻonā e hoʻopili ʻia i ka pae PH makemake ʻia. Hoʻohana pinepine ʻia kēia hopena i ke kaʻina hana hope o ke kaʻina hoʻomākaukau cellulose ether, i ʻole e hoʻoheheʻe ʻia ka cellulose ether, maʻalahi e hoʻohana i ka wai 20 ~ 25 ℃ e holoi a hoʻomaʻemaʻe. Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia nā mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka PH o ka hopena e lilo i alkaline, a ua hoʻoheheʻe koke ʻia ka huahana i ka hopena. Hiki ke hoʻohana ʻia kēia ʻano hana ke hoʻohana ʻia ka cellulose ether solution e hana i kahi kiʻiʻoniʻoni a laila mālama ʻia ke kiʻiʻoniʻoni e hana i kahi kiʻiʻoniʻoni insoluble.
 
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme kū'ē o cellulose derivatives i loko o ke kumumanaʻo, e like me kēlā me kēia hui anhydroglucose e like me ka hui pū ʻana o ka hoʻololi ʻana i nā pūʻulu, ʻoi aku ka liʻiliʻi o ka erosion o nā microorganisms i ka maʻi, akā ʻo ka mea i hoʻopau ʻia e hoʻololi i ka waiwai ma mua o 1, no ka hoʻohaʻahaʻa ʻana i ka enzyme, ʻo ia ka wehewehe ʻana o kēlā me kēia pūʻulu i ka degere pani ʻana o ke kaulahao cellulose ʻaʻole like, hiki i nā microorganisms ke hoʻopau kokoke i ka hoʻololi ʻole ʻia. nā pūʻulu glucose dehydrated e hana i nā kō, hiki ke hoʻomoʻa ʻia e nā microorganism i meaʻai. No laila, inā piʻi ka etherification substitution degere o cellulose, e hoʻonui ʻia ke kūʻē o ka cellulose ether i ka erosion enzymatic. Ua hōʻike ʻia ma lalo o nā kūlana i hoʻomalu ʻia, ʻo ke koena viscosity o hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), a me hydroxyethyl cellulose (1.7%) he 13.2%, 7.3% , 3.8%, a me 1.7%. Loaʻa i ka Hydroxypropyl methyl cellulose ka mana anti-enzyme ikaika. No laila hydroxypropyl methylcellulose anti-enzyme maikaʻi loa, i hui pū ʻia me kona dispersion maikaʻi, mānoanoa a me ka hoʻokumu ʻana i ke kiʻiʻoniʻoni, i hoʻopili ʻia i nā emulsion coatings, etc., ʻaʻole pono e hoʻohui i nā preservatives. Eia nō naʻe, i mea e pale ai i ka mālama lōʻihi o ka hopena a i ʻole ka hoʻohaumia ʻana mai ka honua o waho, hiki ke hoʻohui ʻia nā preservatives, hiki ke hoʻoholo ʻia ke koho e like me nā koi hope o ka hopena. ʻO ka Phenylmercuric acetate a me ka manganese fluosilicate he mau mālama mālama pono, akā he mea ʻawaʻawa lākou a pono e mālama pono ʻia. ʻO ka maʻamau, hiki ke hoʻohui ʻia ka 1 ~ 5mg phenylmercuric acetate i kēlā me kēia lita o ka hopena.
 
7, hydroxypropyl methyl cellulose membrane hana
Hydroxypropyl methyl cellulose hana kiʻiʻoniʻoni o hydroxypropyl methyl cellulose he kiʻiʻoniʻoni maikaʻi loa, ʻo kona ʻano wai a i ʻole nā ​​​​mea hoʻoheheʻe organik, i uhi ʻia ma ka pā aniani, ma hope o ka maloʻo ʻana e lilo i kala ʻole, ʻike a paʻakikī. He kūpaʻa maikaʻi kona maʻamau a paʻa mau i nā wela kiʻekiʻe. E like me ka hoʻohui ʻana o ka plasticizer hygroscopic, hiki ke hoʻonui i kona elongation a me ka maʻalahi, e hoʻomaikaʻi i ka flexure, glycerol a me sorbitol a me nā plasticizer ʻē aʻe ka mea kūpono loa. ʻO ka hoʻonā hopena maʻamau ʻo 2% ~ 3%, ʻo ka plasticizer dosage ʻo 10% ~ 20% o cellulose ether. Inā makemake ʻia ka ʻike o ka plasticizer, hiki ke hōʻemi ʻia ke ʻano o ka colloid dehydration i ka haʻahaʻa kiʻekiʻe. ʻOi aku ka nui o ka ikaika tensile o ka plasticizer kiʻi i hoʻohui ʻia ma mua o ka mea ʻaʻole i hoʻohui ʻia, a piʻi aʻe me ka hoʻonui ʻana o ka nui o ka mea i hoʻohui ʻia, ʻoiai no ka hygroscopicity o ke kiʻi i hoʻonui ʻia me ka piʻi ʻana o ka nui o ka plasticizer.