ʻO ka Hydroxypropylmethylcellulose (HPMC) kahi derivative cellulose i hoʻohana mau ʻia i nā ʻano ʻoihana like ʻole, me nā lāʻau lapaʻau, kūkulu hale a me nā meaʻai. Hiki ke ʻokoʻa kona viscosity ma muli o nā kumu e like me kona kaumaha molecular, degere o ka hoʻololi ʻana, a me ka neʻe ʻana o ka hopena.
Hoʻomaka i ka Hydroxypropyl Methylcellulose (HPMC)
ʻO ka Hydroxypropyl methylcellulose kahi polymer semi-synthetic i loaʻa ma ka hoʻololi kemika o cellulose. Ma muli o kāna mau waiwai kūʻokoʻa, hoʻohana nui ʻia ia e like me ka mānoanoa, gelling agent, film former a stabilizer i nā noi like ʻole.
ʻO ka molekala a me ka haku mele
Aia ka HPMC i ka iwi hope cellulose me ka hydroxypropyl a me ka methoxy substituents. ʻO ka degere o ka hoʻololi ʻana (DS) e pili ana i ka helu awelika o nā mea pani i kēlā me kēia ʻāpana anhydroglucose i ke kaulahao cellulose. Hoʻopili ka waiwai DS kikoʻī i nā waiwai kino a me kemika o HPMC.
HPMC viscosity
He mea koʻikoʻi ka Viscosity no ka HPMC, ʻoi aku ka nui o nā noi e hoʻohana i kāna mau mea mānoanoa a me ka gelling.
Hoʻopili ʻia ka viscosity o nā hoʻonā HPMC e nā kumu he nui:
1. Kaumaha molekula
Hoʻopili ke kaumaha molekala o HPMC i kona viscosity. Ma keʻano laulā, ʻoi aku ka nui o nā HPMC kaumaha molekala e hana i nā hopena viscosity kiʻekiʻe. Loaʻa nā māka like ʻole o ka HPMC ma ka mākeke, kēlā me kēia me kona pae kaumaha molekala ponoʻī.
2. Degree of substitution (DS)
Hoʻopili nā waiwai DS o nā hui hydroxypropyl a me methoxy i ka solubility a me ka viscosity o HPMC. ʻO nā waiwai DS kiʻekiʻe ka hopena i ka hoʻonui ʻia ʻana o ka wai a me nā haʻina manoanoa.
3. Hoʻopaʻa
ʻO ke koʻikoʻi o ka HPMC i ka hoʻonā he kumu nui e pili ana i ka viscosity. Ke piʻi aʻe ka manaʻo, piʻi pinepine ka viscosity. Hōʻike pinepine ʻia kēia pilina e ka Krieger-Dougherty equation.
4. Ka wela
Hoʻopilikia pū ka mahana i ka viscosity o nā hoʻonā HPMC. Ma ka ʻōlelo maʻamau, e emi ana ka viscosity i ka piʻi ʻana o ka mahana.
Nā wahi noi
Lapaʻau Lapaʻau: Hoʻohana maʻamau ʻia ka HPMC i nā hoʻoponopono lāʻau lapaʻau, me nā papa a me nā ʻoluʻolu ophthalmic, kahi e koʻikoʻi ai ka hoʻokuʻu ʻana a me ka viscosity.
Hana: Ma ka ʻoihana kūkulu, hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa i nā huahana sima e hoʻomaikaʻi i ka hana a me ka paʻa ʻana o ka wai.
ʻOihana Meaʻai: Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa, stabilizer a me ka emulsifier i nā noi meaʻai.
ʻO ka viscosity o ka hydroxypropyl methylcellulose kahi waiwai paʻakikī i hoʻopili ʻia e nā mea he nui e like me ke kaumaha molekala, degere o ka hoʻololi ʻana, ka ʻike a me ka mahana. Loaʻa nā māka like ʻole o ka HPMC e kūpono i nā noi kikoʻī, a hāʻawi nā mea hana i nā pepa ʻikepili ʻenehana e wehewehe ana i ka laulā viscosity o kēlā me kēia papa ma lalo o nā kūlana like ʻole. Pono nā mea noiʻi a me nā mea hoʻokumu e noʻonoʻo i kēia mau mea e hoʻoponopono i nā waiwai o HPMC e hoʻokō i nā koi o kā lākou noi i manaʻo ʻia.
Ka manawa hoʻouna: Jan-20-2024