ʻO ka Hydroxypropyl methylcellulose, ka mea maʻamau i kapa ʻia ʻo HPMC, he mea hoʻohana nui i ka lāʻau lapaʻau a me ka meaʻai meaʻai.Ma muli o kona solubility maikaʻi loa, hiki ke hoʻopaʻa ʻia a me nā waiwai hana kiʻiʻoniʻoni, ua hoʻohana nui ʻia i ka ʻoihana lāʻau.Hoʻohana pinepine ʻia ʻo HPMC i ka ʻoihana meaʻai e like me ka mānoanoa, emulsifier a me ka stabilizer.He mea koʻikoʻi ka maʻemaʻe o HPMC i ka ʻoihana lāʻau lapaʻau a me ka meaʻai e pili ana i ka pono a me ka palekana o ka huahana.E kūkākūkā kēia ʻatikala i ka hoʻoholo ʻana o ka maʻemaʻe HPMC a me kāna mau ʻano.
He aha nā HPMC?
ʻO ka Hydroxypropylmethylcellulose (HPMC) he cellulose ether i loaʻa mai ka methylcellulose.ʻO kona kaumaha molekala he 10,000 a 1,000,000 Daltons, a he pauda keʻokeʻo a keʻokeʻo paha, ʻaʻohe ʻala a ʻono ʻole.Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai, a hiki ke hoʻoheheʻe ʻia i loko o kekahi mau mea hoʻoheheʻe kūlohelohe e like me ka ethanol, butanol, a me ka chloroform.Loaʻa iā ia kekahi mau waiwai like ʻole e like me ka paʻa ʻana o ka wai, ka mānoanoa a me ka hiki ke hoʻopaʻa ʻia, kahi kūpono no ka ʻoihana lāʻau lapaʻau a me nā ʻoihana meaʻai.
Ka hoʻoholo ʻana o ka maʻemaʻe HPMC
ʻO ka maʻemaʻe o ka HPMC e pili ana i kekahi mau mea e like me ke kiʻekiʻe o ka hoʻololi ʻana (DS), ka moisture content a me ka ʻona lehu.Hōʻike ʻo DS i ka helu o nā pūʻulu hydroxyl i pani ʻia e nā hui hydroxypropyl i loko o ka mole cellulose.Hoʻonui ke kūlana kiʻekiʻe o ka hoʻololi i ka solubility o HPMC a hoʻomaikaʻi i ka hiki ke hana kiʻiʻoniʻoni.ʻO ka mea ʻē aʻe, ʻo ka haʻahaʻa haʻahaʻa o ka hoʻololi ʻana e hopena i ka hoʻohaʻahaʻa solubility a me nā waiwai hana kiʻiʻoniʻoni maikaʻi ʻole.
Hana Hoʻoholo Maʻemaʻe HPMC
Nui nā ʻano no ka hoʻoholo ʻana i ka maʻemaʻe o ka HPMC, me ka titration acid-base, ka nānā ʻana i ka elemental, high-performance liquid chromatography (HPLC), a me ka infrared spectroscopy (IR).Eia nā kikoʻī no kēlā me kēia ala.
titration acid-base
Hoʻokumu ʻia ke ʻano ma ka hopena neutralization ma waena o nā hui acidic a me nā pūʻulu kumu ma HPMC.ʻO ka mua, ua hoʻoheheʻe ʻia ka HPMC i loko o kahi mea hoʻoheheʻe a ua hoʻohui ʻia kahi leo ʻike o ka waika a i ʻole ka hopena kumu o ka ʻike ʻike.Hoʻokō ʻia ka titration a hiki i ka pae pH i kū ʻole.Mai ka nui o ka waikawa a i ʻole ke kumu i hoʻopau ʻia, hiki ke helu ʻia ke degere o ka hoʻololi ʻana.
Ka nānā ʻana i ka elemental
ʻIke ʻia ka helu ʻeleʻele i ka pākēneka o kēlā me kēia mea i loko o kahi laʻana, me ke kalapona, hydrogen, a me ka oxygen.Hiki ke helu ʻia ke degere o ka hoʻololi ʻana mai ka nui o kēlā me kēia mea i loaʻa i ka laʻana HPMC.
Kiʻekiʻe Hana Liquid Chromatography (HPLC)
ʻO ka HPLC kahi hana analytical i hoʻohana nui ʻia e hoʻokaʻawale i nā ʻāpana o ka hui ʻana ma muli o kā lākou launa pū ʻana me nā pae paʻa a me nā pae kelepona.I loko o ka HPMC, hiki ke helu ʻia ke degere o ka hoʻololi ʻana ma ke ana ʻana i ka ratio o ka hydroxypropyl i nā pūʻulu methyl i kahi hāpana.
ʻIkepili Infrared (IR)
ʻO ka spectroscopy infrared he ʻano analytical e ana i ka absorption a i ʻole ka lawe ʻana o ka radiation infrared e kahi laʻana.Loaʻa i ka HPMC nā piko absorption ʻokoʻa no ka hydroxyl, methyl a me hydroxypropyl, hiki ke hoʻohana ʻia e hoʻoholo i ke ʻano o ka hoʻololi ʻana.
He mea koʻikoʻi ka maʻemaʻe o HPMC i ka ʻoihana lāʻau lapaʻau a me ka ʻoihana meaʻai, a he mea koʻikoʻi kona hoʻoholo ʻana e hōʻoia i ka palekana a me ka pono o ka huahana hope.Loaʻa kekahi mau ala e hoʻoholo ai i ka maʻemaʻe o ka HPMC, me ka titration acid-base, elemental analysis, HPLC, a me IR.Loaʻa i kēlā me kēia ala kona mau pono a me nā hemahema a hiki ke koho ʻia e like me nā koi kikoʻī o ka noi.No ka mālama ʻana i ka maʻemaʻe o ka HPMC, pono e mālama ʻia ma kahi maloʻo a me ka maʻalili mai ka lā a me nā mea haumia ʻē aʻe.
Ka manawa hoʻouna: ʻAukake-25-2023