Nā waiwai o ka hydroxypropyl methylcellulose

ʻO ka Hydroxypropyl methylcellulose HPMC kahi ʻano o ka non-ionic cellulose i hui ʻia eter.ʻAʻole like me ka ionic methyl carboxymethyl cellulose i hui pū ʻia me ka ether, ʻaʻole ia e pane me nā metala kaumaha.Ma muli o nā ʻano like ʻole o ka methoxyl content a me ka hydroxypropyl content i loko o ka hydroxypropyl methylcellulose a me nā viscosities like ʻole, nui nā ʻano like ʻole me nā waiwai like ʻole, no ka laʻana, kiʻekiʻe methoxyl maʻiʻo a me ka haʻahaʻa hydroxypropyl haʻahaʻa. ʻO ka methoxyl content a me ka hydroxypropyl kiʻekiʻe ma kahi kokoke i ka hydroxypropyl methyl cellulose.Eia nō naʻe, i loko o kēlā me kēia ʻano, ʻoiai he liʻiliʻi wale nō o ka pūʻulu hydroxypropyl a i ʻole kahi pūʻulu methoxyl liʻiliʻi i loko, aia nā ʻokoʻa nui i ka solubility i nā mea hoʻoheheʻe organik a i ʻole ka mahana o ka flocculation i loko o nā wai wai.

(1) Nā waiwai hoʻoheheʻe o hydroxypropyl methylcellulose

①Solubility o ka hydroxypropyl methylcellulose i loko o ka wai Hydroxypropyl methylcellulose he ʻano methylcellulose maoli nō ia i hoʻololi ʻia e propylene oxide (methoxypropylene), no laila ua mau nā waiwai like me ka methyl cellulose He ʻano like ka cellulose o ka wai anuanu a me ka wai wela.Eia naʻe, ma muli o ka pūʻulu hydroxypropyl i hoʻololi ʻia, ʻoi aku ka kiʻekiʻe o ka mahana gelation i ka wai wela ma mua o ka methyl cellulose.No ka laʻana, ka viscosity o hydroxypropyl methylcellulose aqueous solution me 2% methoxy content substitution degere DS=0.73 a me ka hydroxypropyl content MS=0.46 he 500 mpa·s ma 20°C, a me kona wela gel Hiki ke hiki kokoke i 100°C, oiai ʻO ka methyl cellulose ma ka mahana like ma kahi o 55°C wale nō.No kona hikiwawe i ka wai, ua hoʻomaikaʻi nui ʻia.No ka laʻana, hiki ke kūʻai ʻia ka pulverized hydroxypropyl methylcellulose (granular shape 0.2 ~ 0.5mm ma 20 ° C me ka 4% aqueous solution viscosity o 2pa•s ma Ma ka lumi wela, hiki ke hoʻoheheʻe ʻia i ka wai me ka ʻole o ke anuanu.

②Ka hoʻoheheʻe ʻia o ka hydroxypropyl methylcellulose i loko o nā mea hoʻoheheʻe organik ʻoi aku ka maikaʻi o ka solubility o ka hydroxypropyl methylcellulose i loko o nā mea hoʻoheheʻe organik ma mua o ka methylcellulose.No nā huahana ma luna o 2.1, kiʻekiʻe-viscosity hydroxypropyl methylcellulose i loaʻa ka hydroxypropyl MS = 1.5 ~ 1.8 a me ka methoxy DS = 0.2 ~ 1.0, me ka huina o ka hoʻololi ʻana ma luna o 1.8, hiki ke hoʻoheheʻe ʻia i ka anhydrous methanol a me ka ethanol solution Medium, a me ka thermoplastic a me ka wai-soluble. .Hiki ke hoʻoheheʻe ʻia i loko o nā hydrocarbons chlorinated e like me ka methylene chloride a me ka chloroform, a me nā mea hoʻoheheʻe kūlohelohe e like me ka acetone, isopropanol a me ka waiʻona diacetone.ʻOi aku ka maikaʻi o kona hoʻoheheʻe ʻana i nā mea hoʻoheheʻe organik ma mua o ka hoʻoheheʻe wai.

(2) Nā mea e pili ana i ka viscosity o ka hydroxypropyl methylcellulose ʻO ka hoʻoholo ʻana o ka viscosity maʻamau o ka hydroxypropyl methylcellulose e like me nā cellulose ethers ʻē aʻe, a ua ana ʻia ma 20 ° C me ka 2% aqueous solution e like me ka maʻamau.Hoʻonui ka viscosity o ka huahana like me ka piʻi ʻana o ka ʻike.No nā huahana me nā kaumaha molekala like ʻole i ka ʻike like, ʻoi aku ka nui o ka viscosity o ka huahana me ke kaumaha molekala nui.Ua like kona pilina me ka wela me ka methyl cellulose.Ke piʻi ka mahana, hoʻomaka ka emi ʻana o ka viscosity, akā ke hiki i kahi mahana.

piʻi koke ka viscosity a puka ka gelation.ʻOi aku ka kiʻekiʻe o ka mahana gel o nā huahana haʻahaʻa-viscosity.kiʻekiʻe.ʻAʻole pili wale kona kiko gel i ka viscosity o ka ether, akā pili pū kekahi i ka ratio haku mele o ka pūʻulu methoxyl a me ka hui hydroxypropyl i ka ether a me ka nui o ka huina hoʻololi.Pono e hoʻomaopopo ʻia he pseudoplastic nō hoʻi ka hydroxypropyl methylcellulose, a paʻa kona hopena i ka mahana o ka lumi me ka ʻole o ka degradation o ka viscosity koe wale nō ka hiki ke hoʻohaʻahaʻa i ka enzymatic.

(3) ʻO ka ʻae ʻana o ka paʻakai o ka hydroxypropyl methylcellulose No ka mea ʻo ka hydroxypropyl methylcellulose he etera non-ionic, ʻaʻole ia e ionize i loko o ka pāpaʻi wai, ʻaʻole like me nā ethers cellulose ionic ʻē aʻe, No ka laʻana, hana ka carboxymethyl cellulose me nā ion metala kaumaha a hoʻoheheʻe ʻia i loko o ka hopena.ʻAʻole e kahe ka paʻakai maʻamau e like me ka chloride, bromide, phosphate, nitrate, a me nā mea ʻē aʻe ke hoʻohui ʻia i kāna wai.Eia nō naʻe, ʻo ka hoʻohui ʻana i ka paʻakai he mea koʻikoʻi i ka wela o ka flocculation o kāna ʻano wai.Ke piʻi aʻe ka paʻakai paʻakai, emi ka mahana gel.Ke emi ka paʻakai ma lalo o ka flocculation point, e piʻi aʻe ka viscosity o ka hopena.No laila, hoʻohui ʻia kahi nui o ka paʻakai., i ka hoʻohana ʻana, hiki ke hoʻokō i ka hopena thickening ʻoi aku ka waiwai.No laila, i kekahi mau noi, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i ka hui ʻana o ka cellulose ether a me ka paʻakai ma mua o kahi kiʻekiʻe kiʻekiʻe o ka hopena ether e hoʻokō ai i ka hopena mānoanoa.

(4) Hydroxypropyl methylcellulose acid a me ka alkali resistance ʻO ka Hydroxypropyl methylcellulose ka paʻa mau i nā waikawa a me nā alkalis, a ʻaʻole pili i ka pae o ka pH 2 ~ 12.Hiki iā ia ke pale i kekahi nui o nā waikawa Light, e like me ka formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, etc. Akā ʻo ka waikawa concentrated ka hopena o ka hoʻemi ʻana i ka viscosity.ʻAʻohe hopena o ka alkali e like me ka soda caustic, caustic potash a me ka wai lime, akā hiki iā lākou ke hoʻonui iki i ka viscosity o ka hopena, a laila hoʻemi mālie.

(5) Hiki ke hoʻohui ʻia ka waiʻona hydroxypropyl methylcellulose Hydroxypropyl methylcellulose me nā pūhui polymer hiki ke hoʻoheheʻe ʻia i ka wai e lilo i ʻano like ʻole a me ka ʻike me ka viscosity kiʻekiʻe.ʻO kēia mau pūhui polymer ka polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinylsiloxane, hydroxyethyl cellulose, a me ka methyl cellulose.ʻO nā pūhui molekala kiʻekiʻe kūlohelohe e like me ka gum arabic, ka ʻūhini ʻūhini, ka karaya gum, a me nā mea ʻē aʻe he kūpono maikaʻi me kāna hoʻonā.Hiki ke hui pū ʻia ka Hydroxypropyl methylcellulose me ka ester mannitol a i ʻole sorbitol ester o ka waikawa stearic a i ʻole ka palmitic acid, a hiki ke hui pū ʻia me ka glycerin, sorbitol a me ka mannitol, a hiki ke hoʻohana ʻia kēia mau pūhui e like me ka hydroxypropyl methylcellulose Plasticizer no cellulose.

(6) Hiki ke hoʻopaʻa ʻia nā etera cellulose hiki ʻole ke hoʻoheheʻe ʻia i ka wai o ka hydroxypropyl methylcellulose me nā aldehydes ma luna o ka ʻili, no laila e hoʻoheheʻe ʻia kēia mau eter hiki ke hoʻoheheʻe ʻia i ka wai i loko o ka hopena a lilo i mea hiki ʻole ke hoʻoheheʻe ʻia i ka wai.ʻO nā aldehydes e hana ai i ka hydroxypropyl methylcellulose hikiʻole ke hoʻoheheʻe i ka formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, a me nā mea'ē aʻe. mea kūʻai ma ka hana ʻoihana.ʻO ka nui o kēia ʻano mea hoʻohui keʻa i loko o ka hopena he 0.2% ~ 10% o ka nui o ka ether, ʻoi aku ka maikaʻi o 7% ~ 10%, no ka laʻana, ʻo 3.3% ~ 6% o glyoxal ka mea kūpono loa.ʻO ka maʻamau, ka lapaʻau

ʻO ka mahana he 0 ~ 30 ℃, a ʻo ka manawa he 1 ~ 120min.Pono e hoʻokō ʻia ka hopena hoʻopili keʻa ma lalo o nā kūlana acidic.ʻO ka mea maʻamau, ua hoʻohui mua ʻia ka hopena me ka waika ikaika inorganic a i ʻole ka waikawa carboxylic organik e hoʻoponopono ai i ka pH o ka hopena ma kahi o 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui i nā aldehydes e hoʻokō i ka hopena cross-linking.ʻO ka waikawa i hoʻohana ʻia he waika hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid a citric acid etc., kahi e pono ai me ka waikawa formic a i ʻole ka acetic acid, a ʻoi aku ka maikaʻi o ka waikawa formic.Hiki ke hoʻohui ʻia ka ʻakika a me ka aldehyde i ka manawa like e ʻae i ka hoʻonā e hoʻokō i ka hopena hoʻohui i loko o ka pae pH makemake ʻia.Hoʻohana pinepine ʻia kēia hopena i ka hana hoʻoponopono hope loa i ka hoʻomākaukau ʻana o ka cellulose ethers.Ma hope o ka pau ʻole o ka cellulose ether, maʻalahi ka hoʻohana

20 ~ 25 ℃ wai no ka holoi a hoʻomaʻemaʻe.Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia nā mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka pH o ka hopena i alkaline, a e hoʻoheheʻe koke ka huahana i ka hopena.Hoʻopili pū ʻia kēia ʻano hana i ka mālama ʻana i ke kiʻiʻoniʻoni ma hope o ka hana ʻana o ka cellulose ether solution i kiʻiʻoniʻoni e hana i kahi kiʻiʻoniʻoni insoluble.

(7) ʻO ke kūpaʻa enzyme o ka hydroxypropyl methylcellulose he derivatives theoretically cellulose, e like me kēlā me kēia hui anhydroglucose, inā aia kahi pūʻulu substituent paʻa paʻa, ʻaʻole maʻalahi ka maʻi ʻia e nā microorganisms, akā ʻo ka mea i hoʻopau ʻia ke ʻoi aku ka waiwai o ka hoʻololi. 1, e hoʻohaʻahaʻa ʻia hoʻi ia e nā enzymes, ʻo ia hoʻi, ʻaʻole kūlike ka pae o ka hoʻololi ʻana o kēlā me kēia hui ma ke kaulahao cellulose, a hiki i nā microorganisms ke hoʻopau i ka pūʻulu anhydroglucose unsubstituted e hana i nā sugars, e like me nā meaʻai no nā microorganisms e komo.No laila, inā piʻi ka degere o ka hoʻololi ʻana i ka cellulose, e piʻi pū ke kū'ē i ka erosion enzymatic o cellulose ether.Wahi a nā hōʻike, ma lalo o nā kūlana i kāohi ʻia, nā hopena hydrolysis o nā enzymes, ke koena o ka viscosity o hydroxypropyl methylcellulose (DS = 1.9) he 13.2%, methylcellulose (DS = 1.83) he 7.3%, methylcellulose (DS = 1.66) he 3.8%, a ʻo ka hydroxyethyl cellulose he 1.7%.Hiki ke ʻike ʻia he ikaika anti-enzyme ka hydroxypropyl methylcellulose.No laila, ʻo ke kūpaʻa enzyme maikaʻi loa o ka hydroxypropyl methylcellulose, i hui pū ʻia me kona dispersibility maikaʻi, ka mānoanoa a me nā waiwai hana kiʻiʻoniʻoni, hoʻohana ʻia i ka wai-emulsion coatings, etc., a ʻaʻole pono e hoʻohui i nā preservatives.Eia nō naʻe, no ka mālama lōʻihi o ka hopena a i ʻole ka hoʻohaumia ʻana mai waho, hiki ke hoʻohui ʻia nā preservatives i mea e mālama ai, a hiki ke hoʻoholo ʻia ke koho e like me nā koi hope o ka hopena.ʻO ka Phenylmercuric acetate a me ka manganese fluorosilicate nā mea mālama pono, akā loaʻa iā lākou a pau ka Toxicity, pono e uku ʻia ka nānā ʻana i ka hana.ʻO ka maʻamau, hiki ke hoʻohui ʻia ka 1 ~ 5mg o ka phenylmercury acetate i ka hopena no ka lita o ke ʻano.

(8) ʻO ka hana o ka hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose he mau waiwai hana kiʻiʻoniʻoni maikaʻi loa.Hoʻopili ʻia kāna ʻano wai a i ʻole nā ​​​​mea hoʻoheheʻe organik ma luna o kahi pā aniani, a lilo ia i kala ʻole a ʻākala ma hope o ka maloʻo ʻana.A kiʻiʻoniʻoni paʻakikī.He kūpaʻa maikaʻi kona maʻamau a paʻa mau i nā wela kiʻekiʻe.Inā hoʻohui ʻia ka plasticizer hygroscopic, hiki ke hoʻonui ʻia kona elongation a me ka maʻalahi.Ma ke ʻano o ka hoʻomaikaʻi ʻana i ka maʻalahi, ʻo nā plasticizers e like me glycerin a me sorbitol ka mea kūpono loa.ʻO ka maʻamau, ʻo 2% ~ 3% ka hopena o ka hopena, a ʻo ka nui o ka plasticizer he 10% ~ 20% o cellulose ether.Inā kiʻekiʻe loa ka ʻike o ka plasticizer, e hoʻemi ʻia ka colloidal dehydration i ka haʻahaʻa haʻahaʻa.ʻO ka ikaika tensile o ke kiʻi me

ʻOi aku ka nui o ka plasticizer i hoʻohui ʻia ma mua o kēlā me ka ʻole o ka plasticizer, a hoʻonui ia me ka hoʻonui ʻana o ka nui i hoʻohui ʻia.No ka hygroscopicity o ke kiʻiʻoniʻoni, hoʻonui ia me ka hoʻonui ʻana o ka nui o ka plasticizer.